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Blogs

We welcome blog submissions from all Wyatt users and staff. To submit a blog, please send your article in a Word document to This email address is being protected from spambots. You need JavaScript enabled to view it. along with any photos or images in separate files.

Wyatt presents Polymer Characterization seminar hosted by the University of Minnesota
April 13, 2017
– Wyatt Technology, in partnership with the University of Minnesota, presented a polymer characterization seminar in the Twin Cities to over fifty scientists and engineers.  Dr. Jeff Ahlgren was the keynote speaker and discussed ways in which size-exclusion chromatography (SEC) or gel permeation chromatography (GPC) coupled with multi-angle light scattering (MALS), refractive index (RI) and differential viscometry can be a powerful technique in determining important polymer characteristics such as: absolute molar mass, size, branching and conformation. Many of our long time and loyal customers attended and got a chance to hear about the latest developments at Wyatt Technology including the new, benchmark-setting ViscoStar III.

Wyatt staff gathers for ribbon-cutting ceremony at new facility
April 4, 2017 - Most of the boxes have been unpacked. Furniture that didn’t survive the move has been recycled. New logos have been stenciled on the glass. Our company sign has been hoisted into place on the building’s façade.

Reviewer's Choice Awarded for DAWN HELEOS II
March 14, 2017 - At the recent Pittsburgh Conference (PittCon) held in Chicago, IL March 6-9, 2017, Wyatt Technology was pleasantly surprised to learn that we had won a Scientist’s Choice Award® from SelectScience. The active roster of 300,000+ SelecScience customers were invited to participate in the process by nominating, voting and reviewing companies of their choosing.

DynaPro High-Throughput Dynamic Light Scattering Now Available with 21CFR11 Compliance
March 3, 2017 - We are pleased to announce the release of 21CFR(11)-compliant software for the groundbreaking DynaPro® Plate Reader II. The DynaPro PRII is widely used in the biopharmaceutical industry to characterize aggregation as well as thermal, conformational and colloidal stability of biotherapeutics. With the release of the 21CFR11-compliant Security Pack (SP) in DYNAMICS, labs operating under GLP or GMP regulatory requirements may now take advantage of the DynaPro PRII’s automation to measure dozens, hundreds or even thousands of samples per day. DYNAMICS SP also supports the DynaPro NanoStar cuvette-based DLS detector and the Möbius zeta potential/DLS detector.

New Application Note: Assessing Ligand-Binding Assay Reagent Proteins by SEC-MALS
March 3, 2017 - Ligand Binding Assays (LBAs) used for large molecule drug development often utilize proteins conjugated to various tags. To ensure that these conjugated protein reagents perform consistently over time and provide high quality data, each lot of conjugated material should be characterized functionally and biophysically. This application note, contributed by Justin Low et al. at Genentech, discusses the advantages of SEC-MALS for this application and the impact of aggregated reagents on assays used to detect anti-drug antibodies.

Webcast: High Throughput Tools for Optimizing Drug Nanosuspensions
February 2, 2017 - Listen to this on-demand webcast to learn how Dr. Dennis Leung of Merck & Co. (currently at Genentech) has implemented high-throughput process development tools for drug nanosuspensions, utilizing high-throughput dynamic light scattering for rapid analytical feedback.

Featured article: Algorithm-driven high-throughput screening of colloidal nanoparticles under simulated physiological and therapeutic conditions
February 14, 2017 - Testing the stability of nanoparticles for drug delivery, phototherapy and diagnostics under physiological conditions is a critical phase of development. Bhirde et al. of the FDA and NIH have demonstrated the use of the DynaPro DLS Plate Reader for assessing the stability of model colloidal systems and their interaction with serum albumin, fully automated over many samples conditions and an extended time period.

Webcast: The Molecular Tool-kit of Hemorrhagic Fever Viruses
February 2, 2017 - The ability of viruses to maximize functionality from a limited genome, and to evolve their functionalities in real time offers us fundamental insights into the capabilities and plasticity of proteins in general. In this on-demand webcast, Dr. Erica Ollmann Saphire of the Scripps Research Institute explores the versatile structural biology of viral proteins and how light scattering played a key role in her discoveries.

Screening Developability and Pre-Formulation of Biotherapeutics with High-Throughput Dynamic Light Scattering (HT–DLS)
February 2, 2017 - Learn how high-throughput dynamic light scattering meets the challenges of aggregation and stability studies in early developability and pre-formulation studies of biotherapeutics. Newly released white paper.

ViscoStar III - Innovations in Online Viscometry for GPC
January 21, 2017 - The ViscoStar III comprises breakthrough technology for online viscometry, enhancing sensitivity and resolution while improving ease-of-use and nearly eliminating sensitivity to pressure fluctuations from the HPLC pump or other sources. This white paper describes the innovations and the end benefits to users.

We’re moving! Just not very far...
January 9, 2017 - Yes, it’s true. Wyatt Technology is moving its premises in January 2017. For those of you who have known—and loved—our location at 6300 Hollister Avenue, do not fret. We are moving about 100 meters away to 6330 Hollister Avenue.

Wishing you the best of Holidays
December 22, 2016 - On behalf of our entire company, I wanted to take this opportunity to wish you and your families a wonderful holiday season. The end of the year is, in its own way, a commencement of the New Year, and our company has enjoyed 34 years of prosperity thanks to your business.

Commercializing multi-angle light scattering instruments - an interview with Philip Wyatt

November 11, 2016 - The fascinating story behind the origins of MALS instrumentation that revolutionized absolute molar mass and size analysis of proteins, polymers and nanoparticles.

Sigma Xi inducts 12 Wyatt Technology scientists
October 26, 2016 - Sigma Xi Inducts 12 Wyatt Technology Scientists October 26, 2016-Wyatt Technology proudly announces that eleven of its scientists have been inducted into Sigma Xi, The Scientific Research Society. Sigma Xi is the world’s largest, multidisciplinary honor society for scientists and engineers.

Cutting edge women use cutting edge instruments
October 18, 2016 - If you were watching the Today Show on Monday, October 17, 2016 you would have seen at least one segment not related to politics. In fact, “Cutting Edge Women”, is a regular part of the Today Show. As you might guess, it’s about influential women and this episode featured Anne Wojcicki, the founder and CEO of 23andMe, a genetic testing company in the Bay Area of California. 23andMe is also of greater interest to Wyatt Technology because Anne Wojciki’s company is a customer of our technology.

Chemistry Nobel Prize awarded to Sir J. Fraser Stoddart
October 5, 2016 - Wyatt Technology congratulates its customer, Sir J. Fraser Stoddart of Northwestern University on sharing the Nobel Prize in Chemistry today with Bernard L. Feringa and Jean-Pierre Sauvage. They have developed molecules with controllable movements, which can perform a task when energy is added. We are delighted to see their work on nano-motors recognized as the building blocks for future molecular machines. Some of Professor Stoddart’s publications using our DAWN instruments may be found in our Bibliography.

Highlights: Light scattering reveals novel applications of DNA
March 29, 2016 - Deoxyribonucleic acid (DNA) is an amazingly versatile molecule thanks to its unique structure and stability. Encoding and passing on to subsequent generations all inheritable genetic information, the DNA molecule plays a well-known, pivotal role in the biological world. However, DNA has also been the subject of cutting-edge research in fields outside the usual scope of genetics and biology, from nanotechnology and nanoelectronics to drug delivery and even optogenetics, taking advantage of its highly customizable properties. Light scattering, of course, plays an important part in many of these studies.

The myriad applications of quantitative light scattering in the biological and biopharmaceutical sciences
March 28, 2016 - Actually too numerous to cover in a single publication, but Allen Minton of the Laboratory of Biochemistry and Genetics in NIH’s National Institutes of Diabetes and Digestive and Kidney Diseases has done a spectacular job of critically addressing quite a few. His review article, “Recent applications of light scattering measurement in the biological and biopharmaceutical sciences,” appears in Analytical Biochemistry 501 (2016) pp. 4-22.

Retooling protein characterization
February 15, 2016 - Dr. Lisa Heiden of Genetic Engineering & Biotechnology News states if the Biotherapeutics Workshop is to progress beyond Rough-Hewn Products, it will need a range of finely calibrated analytical Platforms. DLS (dynamic light scattering) assesses size distribution, and MALS (multiangle light scattering) measures molar mass. Both are utilized throughout drug discovery, beginning with quality assessments of proteins to identify the best candidate molecules.

ZoBio optimizes solution behavior of proteins
February 10, 2016 - ZoBio Staff In many projects, the largest hurdle to be overcome is preparation of a protein that is well-behaved for biophysical and structural biological studies. Often even after achieving high level expression of a soluble, functional variant of the target, it may aggregate under the high concentrations required for many experimental techniques, particularly NMR and X-ray crystallography.

Wyatt’s International Light Scattering Colloquium focuses on the nano world
January 27, 2016 - Dr. Robert L. Stevenson presents highlights from the 24th ILSC in American Laboratory. Featured talks include those by Erica Ollmann Saphire of Scripps Research Institute, Frank von der Kammer of the University of Vienna, Joseph Arndt of biogen, David Cistola of University of North Texas Health Science Center and Joseph Glajch of Momenta Pharmeceuticals.

Light scattering in the nano world
January 20, 2016 - Methods for the analysis of nanoparticles have been available since the 1980s and light scattering offers one of the most versatile sets of characterization tools. The three most common variations of analytical light scattering includes: multi-angle, dynamic and electrophoretic (MALS, DLS and ELS, respectively). The light scattering toolbox comprising MALS, DLS and ELS is an essential kit for scientists and engineers working in nanoparticle characterization.

Protein formulation consortium
December 16, 2015 - Scientists in the fields of structural biology, biophysics, protein formulation and stability have formed a consortium, Protein-excipient Interactions and Protein-Protein Interactions in Formulation (PIPPI). PIPPI’s goals are a mechanistic understanding of protein stability, as well as training a new generation of innovative and entrepreneurial early-stage researchers who will develop methodologies and tools to guide the formulation of robust biologics. Three-year scholarships are available for 15 Ph.D. students.

Recent publications in the field of natural polymers
December 15, 2015 - Natural polymers and their derivatives feature in a host of cutting-edge applied research projects, including biofuels, environmentally friendly structural materials, nanopharmaceuticals and food science. Light scattering is, of course, a primary means for characterizing natural polymers in terms of molar mass, size, and conformation. Here we present some highlights of recent publications utilizing MALS to study polymerization, structure and degradation of natural polymers, and even the contribution of these materials to the texture and consistency of one of our favorite mobile phases: beer.

The chromatography detector you shouldn't miss
Nov. 20, 2015 - The question of 'Which chromatography detector should I buy' was addressed in a recent LinkedIn post, which gave a great overview of the various detectors available for many types of chromatography, but only briefly alluded to the most important detector type for anyone running size-exclusion chromatography (SEC) or gel-permeation chromatography (GPC): multi-angle light scattering (MALS).

Wyatt Technology’s growth continues…
Nov. 18, 2015 - Wyatt Technology Europe GmbH, Wyatt Technology's subsidiary office in Dernbach, Germany, has expanded its headquarters. The grand opening ceremony of the new European center of operations was held in conjunction with the European Users' Meeting, September 29th through October 2nd, 2015

ILSC 2015: Scattered Light
November 15, 2015 - Wyatt Technology hosted the 24th International Light Scattering Colloquium bringing together dozens of scientists to discuss the use of light scattering in diverse applications from polymer science and nanoparticles to viruses and therapeutic proteins.

   

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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.



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