Upcoming Live Webinars
Real-Time Monitoring of AAV CQAs in a Chromatographic Polishing Step
Join us for a webinar on Tuesday, April 9 at 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST
Downstream purification and enrichment of full capsids for AAV-based gene therapy products, along with aggregate removal, is typically accomplished by ion-exchange chromatography (IEX). Development of this process usually requires sending multiple fractions for offline analysis for each iteration of process conditions, creating a bottleneck that holds back time-to-market and burdens both the development and analytical teams.
Real-time multi-angle light scattering (RT-MALS) is a process analytical technique that quantifies biophysical attributes of AAVs including Vg/Cp, titer and aggregation. RT-MALS provides immediate, high-density feedback on critical quality attributes (CQAs) during the chromatography run, eliminating burdensome offline analyses, and enables optimized control over the collection of purified product. This webcast will present RT-MALS basics and case studies for accelerated AAV process development in a CDMO.
Recent Webinars
Previous webinars may be viewed in our Webinar Library. The following recent webinars are now available:
Request: Exploring Enhanced Macromolecular and Nanoparticle Analysis through the Integration of DLS/ELS/SLS with the ZetaStar Instrument
Sophia Kenrick, Ph.D., Waters | Wyatt Technology, and Richard Chung, Waters | Wyatt Technology
March 15, 2024Request: Leveraging Advanced Analytical Technologies to Expedite the Development of Antibody Drug Conjugates
Eric Miller, Ph.D., Abzena, and Colette Quinn, Ph.D., Waters | Wyatt Technology
February 28, 2024Request: Supporting Sustainability: A Comprehensive Case Study on PLGA and PLA Polymer Characterization and Optimization Using Light Scattering with Triple Detection
Stepan Podzimek, Ph.D., Waters | Wyatt Technology
February 13, 2024Request: Smaller Particle and Low Adsorption Columns for Fast and Efficient Characterization of AAV through SEC-MALS
Bala Addepalli, Ph.D., Waters
January 31, 2024Request: Towards Well-Characterized Proteins and Protein Conjugates Using SEC-MALS
Michelle Chen, Ph.D., Waters | Wyatt Technology
January 17, 2024Request: In-Line and On-Line Monitoring of CQAs for Biologics, Vaccines and Gene Vectors
Daniel Some, Ph.D., Waters | Wyatt Technology
December 5, 2023Request: Successful SEC-MALS analysis of proteins and AAVS
Leo Liu, Ph.D., Waters | Wyatt Technology
July 11, 2023 & November 22, 2023Request: Determination Critical Product Parameters for Proteins from Research to Production
David Golonka, Ph.D., Waters | Wyatt Technology, and Felix Deluweit, Ph.D., Waters | Wyatt Technology
November 8, 2023Request: Multi-Attribute Quantification of Viral Vectors Using Light Scattering
Martin Kurnik, Ph.D., Waters | Wyatt Technology
November 1, 2023Request: Optimizing Development and Release Efficiency of Protein, AAV and LNP Therapies Using Multi-Attribute Quantification (MAQ) Light Scattering
Michelle Chen, Ph.D., Waters | Wyatt Technology
November 1, 2023Request: Shining Light on AAVs: Using Light Scattering Technologies to Solve Challenges in Characterization
Steven Milian, M.S., Thermo Fisher Scientific, Gennarino Del Bagno, Thermo Fisher Scientific, and Sophia Kenrick, Ph.D., Waters | Wyatt Technology
October 18, 2023Request: Advances in Automated Dynamic Light Scattering Characterization and Zeta Potential of Macromolecules and Nanoparticles
Sophia Kenrick, Ph.D., Waters | Wyatt Technology and Richard Chung, Waters | Wyatt Technology
October 10, 2023Request: Unraveling the Complexity: Advanced Analysis of Polymeric Nanostructures
Susanne Boye, Ph.D., Institut Makromolekulare Chemie and Robert Mildner, Ph.D., Waters | Wyatt Technology
August 29, 2023
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