Molecular architecture of the transport channel of the nuclear pore complex

Nobel laureate G. Blobel and colleagues at The Rockefeller University have determined the crystal structure of the nucleoporin interacting domains, Nup54·Nup58 and Nup62·Nup54. These nucleoporins are thought to modulate the ring diameter of receptors and transport activity of the central channel for mammalian nucleocytoplasmic transport. Wyatt Technology's DAWN HELEOS, DynaPro Titan, and Optilab rEX were utilized to determine the molar masses for Nup58-2 protomer and Nup54-4.

Solmaz, S. R.; Chauhan, R.; Blobel, G.; Melčák, I. Cell   2011, 147, 590-602. DOI: 10.1016/j.cell.2011.09.034