Wyatt Technology

Charge it! Electrophoretic Mobility as a Tool for Characterizing Nanoparticle Stability

 

Presented Live: June 2, 2015

Zeta potential is an indispensable measurement commonly used to guide efforts to control stability of particle suspensions. The recent surge of nanoparticle applications has challenged instruments that were designed for analyzing colloids and emulsions. This webinar presents new developments in instrumentation that have expanded the range and methods of zeta potential measurements.

Determination of zeta potential requires knowledge of both electrophoretic mobility and size. These are usually measured sequentially and can potentially damage fragile biomolecules due to high applied voltage. The advances in phase analysis light scattering, described in the webinar, enable highly sensitive measurements to be conducted rapidly at low voltage. They also provide real-time monitoring of samples by simultaneous dynamic light scattering to detect potential degradation, in addition to providing the requisite size data. In addition, sample collection can now be fully automated with an auto-sampler to allow unattended operation. Applications presented will include characterization of drug conjugates, vaccine adjuvants, proteins, and gold nanoparticles.

 

 

 

   

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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.



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