Wyatt Technology

High-throughput Analytics for Formulation and Process Development of Bio- and Nano-therapeutics

 

Speaker: Daniel Some, Ph.D. Principal Scientist
Presented Live: April 12, 2017

Timely, effective development of therapeutic proteins and nanoparticles requires comprehensive analytics across a variety of conditions, excipients, and candidate molecules.

A versatile and powerful method for obtaining these analytics is high-throughput dynamic light scattering (HT-DLS), performed in low-volume microwell plates. While DLS is widely used to characterize size and aggregation of particles from nanometers to microns, HT-DLS extends those measurements to cover a diverse array of screening techniques designed to weed out low-performing formulations prior to costly stability studies.

This webinar will cover the use of HT-DLS in evaluating size, aggregation, colloidal stability, and conformational stability of proteins and nanoparticles in the context of screening formulation and process development conditions.

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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.



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