Wyatt Technology

High Throughput Tools for Optimizing Drug Nanosuspensions

 

Presented Live: November 5, 2015

Speaker: Dr. Dennis Leung, Merck & Co. Inc.

Nanotechnology has emerged as a powerful new platform for the pharmaceutical industry to help develop new drug therapies and has had a significant impact on drug development from preclinical toxicology studies to commercial marketed products. For example, in the Discovery space, increasing exposure multiples in preclinical species has been a formulation challenge in addressing potential safety issues of drug candidates and nanosuspensions are a potential enabling formulation technology to achieve this while providing line of sight into development and clinical manufacture.

Drug nanoparticles have unique properties that can provide advantages for drug delivery. Due to their small size, nanoparticles increase the bioavailability of poorly water-soluble drugs through increased dissolution rate due to their large surface area. By optimizing the formulation, stable drug nanoparticles with high drug loadings can be achieved. In addition, nanoparticles can be successfully dosed through a wide range of administration routes, ranging from oral, intraperitoneal, intravenous, inhalation, and topical delivery. An overview of current nanotechnology approaches, optimization of formulation parameters, high throughput analytical capabilities, and case studies will be presented.

 

 

   

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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.



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