Multi-Angle static Light Scattering (MALS) measures molar mass directly, in solution. Combined with a fractionation technique like Size Exclusion Chromatography (SEC) or Field-Flow Fractionation (FFF), MALS determines absolute molar mass distributions—independent of elution time and as the molecule exists in solution.
The size of macromolecules or nanoparticles is measured via two light scattering methods: MALS and Dynamic Light Scattering (DLS). Each technique contributes critical pieces of the characterization puzzle.
Biomolecular interactions are key to understanding a host of phenomena ranging from structure-function relationships and biotherapeutic activity through stability and aggregation.
Shape, structure or conformation of macromolecules and nanoparticles are analyzed quantitatively via MALS, differential viscometry, and DLS.
The combination of MALS, UV and refractive index (RI) detection with SEC, plus ASTRA's Conjugate Analysis algorithm, offers the solution to the characterization of conjugated macromolecules.