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MP-PALS

Electrophoretic Light Scattering (ELS) is used widely for characterizing electrophoretic mobility, zeta potential or charge of nanoparticles. Wyatt Technology's breakthrough Massively Parallel Phase Analysis Light Scattering (MP-PALS) extends robust ELS measurements to proteins and other biomolecules in native buffer solutions.

MP-PALS does everything conventional zeta potential instruments can do and much more:

  • Optimize stability of colloidal suspensions or biomolecular formulations
  • Evaluate degradation due to accelerated stress of proteins
  • Understand the different factors contributing to intermolecular forces
  • Analyze compositional variants of biopolymers
Mobility Graph

Protein electrophoretic mobility as a function of formulation pH.

MP-PALS Detectors
MP-PALS utilizes low voltage and multiple low-noise, high-dynamic range detectors in parallel to achieve
the highest sensitivity without damaging fragile samples.

 

   

For essential macromolecular and nanoparticle characterization—The Solution is Light™

13 Key Questions to Ask

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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.



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