Wyatt Technology

2015 Focus Meeting

Method development for light scattering applications
in the formulation of biotherapeutics


This one day focus meeting, held on November 5, 2015 directly after the ILSC, addressed practical issues encountered in light scattering applications to biologic and small-molecule therapeutic formulation. Guest speakers from industry as well as Wyatt scientists discussed how they meet these challenges.

 

Guest Speakers

Dennis Leung, Ph.D. - Merck & Co.
Principal Scientist, Discovery Pharmaceutical Sciences Group, Merck Research Laboratories

High-Throughput Tools for Optimizing Drug Nanosuspension Formulations

Dennis Leung 

Michael Marlow, Ph.D. - Regeneron Pharmaceuticals
Senior Staff Scientist, Biochemical and Biophysical Characterization

Challenges in Biotherapeutic Coformulation, Opportunities for Light Scattering

Michael Marlow 

Martijn Schenning, Ph.D. - Janssen
Senior Scientist, Vaccine Process and Analytical Development

Vaccine Product Characterization by AF4-MALS: Particle Size Distribution and Aggregation

Martijn Schenning 

Introductory and advanced light scattering courses covered introductions to techniques such as SEC-MALS, FFF-MALS, DLS, and CG-MALS, as well as offering refreshers on ASTRA or DYNAMICS software. The series of half-day courses were held at Wyatt Technology HQ, and were not only a great way to prepare for ILSC, but also a good excuse for traveling to Santa Barbara in November!

Course Title and Description
Time

Introduction to Light Scattering - Basics of multi-angle and dynamic light scattering: theory, instrumentation, and primary applications.

AM

ASTRA 6 - Refresher on ASTRA plus latest features and improvements and advanced training opportunities in SEC-MALS.

AM

DYNAMICS 7 - Refresher on DYNAMICS plus latest features and improvements and advanced training opportunities in DLS.

PM

FFF-MALS - Theory and use of Field-Flow Fractionation + Light Scattering (FFF-MALS) for separation and characterization of macromolecules and nanoparticles using the Wyatt Eclipse. Students should be familiar with Wyatt MALS instruments and ASTRA.

PM

CG-MALS - Theory and use of Composition-Gradient Light Scattering (CG-MALS) for characterization of biomolecular interactions using the Wyatt Calypso. Students should be familiar with Wyatt MALS instruments.

AM

MP-PALS - Theory and use of Phase Analysis Light Scattering with the Möbiuζ for characterization of macromolecular charge and nanoparticle zeta potential.

PM

 

Wyatt's 24th ILSC "Light Scattering in the Nano World" was held on November 3-4, 2015 at the Four Seasons Biltmore Resort in Santa Barbara, CA.

View the ILSC 2015 schedule.

View 2015 ILSC Photos.

Read a review by Dr. Robert L. Stevenson in American Laboratory.


Plenary Speakers

Vince Hackley, Ph.D. - National Institute of Standards and Technology
Project Team Leader, Nanoparticle Metrology for Health and the Environment

Quantitative Analysis of Functional Nanoparticles with an Introduction to NIST Reference Material Development for Nanotechnology Characterization

Vince Hackley

Frank von der Kammer, Ph.D. - University of Vienna
University Assistant, Vice Head of the Dept. of Environmental Sciences, Head of the Nanogeosciences Division and the Nanoparticle Analysis Laboratory

FFF-MALS-ICPMS Methods for the Analysis of Nanomaterials in Substances and Products

Frank von der Kammer

Paul Russo, Ph.D. - Georgia Tech
Professor of Materials Science and Engineering, Hightower Chair in Biopolymers

Light Scattering Measurements of Anisotropic Polymers and Colloids: Milking the Non-spherical Cow

Paul Russo

Philip Wyatt, Ph.D. - Wyatt Technology Corporation
CEO

Light Scattering and Nanoparticles… from its Long History to Proteins and Various Structures

Philip Wyatt

Light Scattering in Life Sciences, Chemistry and Biotechnology

Joseph Arndt, Ph.D. - Biogen
Senior Scientist, Chemistry & Molecular Therapeutics

Challenges of Maintaining Structure-Function Complexity of Protein Biologics Throughout the Manufacturing Process

Joseph Arndt

David Cistola, M.D., Ph.D. - University of North Texas Health Science Center
Vice President for Research & Innovation, Professor of Integrative Physiology & Anatomy, and Principal Investigator of the Nanoparticle Diagnostics Research Center

Profiling Nanoparticle and Microparticle Distributions in Human Blood using Dynamic Light Scattering and Other Biophysical Methods

David Cistola

Joseph Glajch, Ph.D. - Momenta Pharmaceuticals
Director of Analytical Development

SEC-MALS for the Characterization of Complex Drugs and Sugar-Protein Complexes of Immunological Importance

Joseph Glajch

Erica Ollmann-Saphire, Ph.D. - Scripps Research Institute
Professor of Immunology & Microbial Science; Co-Director, Center of Excellence, Global Virus Network

The Molecular Toolkit of Viral Hemorrhagic Fevers

Erica Ollmann-Saphire

Brian Shoichet, Ph.D. - UC San Francisco
Professor of Pharmaceutical Chemistry

Colloidal Aggregation in Drug Discovery & Pharmacology

Brian Shoichet

 


Short Courses were held Nov. 2, 2015

Introductory and advanced light scattering courses covered introductions to techniques such as SEC-MALS, FFF-MALS, DLS, and CG-MALS, as well as offering refreshers on ASTRA or DYNAMICS software. The series of half-day courses were held at Wyatt Technology HQ, and were not only a great way to prepare for ILSC, but also a good excuse for traveling to Santa Barbara in November! View course schedule.

 

Focus Meeting was held Nov. 5, 2015

A one day meeting focusing on method development for light scattering applications in the formulation of biotherapeutics was held after ILSC and addressed practical issues encountered in light scattering applications to biologic and small-molecule therapeutic formulation. Guest speakers from industry as well as Wyatt scientists discussed how they meet these challenges. View Focus Meeting schedule.

 

For more information, please contact This email address is being protected from spambots. You need JavaScript enabled to view it.

 

2011 FFF Focus Meeting

The 2011 Eclipse Field-Flow Fractionation (FFF) - MALS Focus Meeting was held on November 2nd at the Four Seasons Biltmore Resort in Santa Barbara, CA.

The meeting was dedicated to the exchange of experiences between users of the Eclipse FFF system, and focused on protein, biopolymers and liposome/virus particle applications. The meeting consisted of round-table discussions, structured along different topics. For each session there was a talk given by an expert in the corresponding topic as an introduction to the general discussion.


Speakers

  • Dr. Wei Gao, Dow Chemical Company
    "Probe the TiO2-Polymer Composite Formation in a New Class of Latex Paint by AFFFF-MALS"

  • Dr. Christoph Johann, Wyatt Technology Europe GmbH
    "New Developments in Flow-FFF Instrumentation: Hollow-Fiber Flow-FFF and Frit-Inlet Flow-FFF"

  • Mr. Joey Pollastrini, Amgen Inc.
    "FFF Applied in Biotech: Case Scenarios and Commentary"

  • Mr. Michael Smith, Georgia Institute of Technology
    "AF4-MALS for Temporal Analysis of Degradable Nanogels"

  • Dr. Frédéric Violleau, Ecole d'Ingénieurs de Purpan
    "Analysis of Food Protein with AsF1FFF-MALS"

FFF MeetingRead about our 2010 FFF-MALS Focus Meeting in the American Laboratory Journal!


See what happened in previous years!

2010 Eclipse FFF Focus Meeting

2009 Eclipse FFF Focus Meeting

2008 Eclipse FFF Focus Meeting

2007 Eclipse FFF Focus Meeting

 

   

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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.



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