Upcoming Live Webinars

Advances in Downstream PAT for Biologics, Vaccines and Gene Vectors

Join us for a webinar on Tuesday, August 23 at 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST

Rapid process development and scale-up of novel complex drugs, as well as reliable unit operations during commercial production, require advanced PAT tools, capable of providing timely feedback on product attributes. Real-time multi-angle light scattering (RT-MALS) determines key biophysical product attributes, including molar mass, particle size and particle concentration. These attributes are further indicative of quality attributes such as titer, aggregation and full-empty ratio, and may be used for process control as well as quality monitoring.

This webcast will review the principles, capabilities and limitations of RT-MALS, and then present case studies covering downstream processing (DSP) of viral vectors, proteins and polysaccharides, as well as formulation, production and purification of lipid nanoparticles.


Comparing Methods that Determine Empty-Full Ratio of AAV Capsids

Join us for a webinar on Tuesday, September 20 from 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST

The relative abundance of empty and full AAV capsids in gene therapy vector preparations is a critical quality attribute. A variety of methods are available to perform these measurements including SEC-MALS, which combines separation by size-exclusion chromatography with detection by multi-angle light scattering, UV/Vis, and differential refractometry. However, there are relatively few reports that compare these methods. This webinar compares the outcomes of numerous orthogonal characterization methods on a single vector preparation. We find that SEC-MALS not only provides favorable performance for quality control and product development applications, but that it is uniquely situated to be established as a platform method for the semi-quantitative measurement of empty/full ratios across AAV serotypes, transgenes, and manufacturing processes.


Advantages of FFF-MALS over SEC-MALS for the Determination of Molar Mass and Size Distribution of Polysaccharides

Join us for a webinar on Tuesday, September 27 at 10:00 AM CEST

Size-exclusion chromatography (SEC) has been widely used for the determination of molar mass and molar mass distribution of various natural biopolymers. However, the lack of appropriate calibration standards and non-ideal separation due to column interactions often causes misleading and incorrect results.

This webinar explores the capabilities of the two separation techniques SEC and field-flow fractionation (FFF) for characterizing the molar mass, size as well as distribution of sulfated polysaccharides extracted from brown algae, none as fucoidan. Most of the non-ideal separation can be eliminated by applying the alternative separation technique FFF.


Recent Webinars

Previous webinars may be viewed in our Webinar Library. The following recent webinars are now available:

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