Upcoming Live Webinars

Real-Time MALS:
A Breakthrough in Process Analytical Technology for
Nanoparticles, Biopharmaceuticals and Polymers

Join us for a webinar on February 26 at 8:00 AM PST | 11:00 AM EST | 17:00 CET

Multi-angle light scattering (MALS) is primarily used with size-exclusion chromatography (SEC) or field-flow fractionation (FFF) to characterize macromolecules and nanoparticles in solution. SEC-MALS and FFF-MALS determine distributions of molecular weight (M_W) and size (rms radius, R_g), which are key attributes determining the quality of advanced pharmaceuticals and biopharmaceuticals such as monoclonal antibodies, vaccines, gene vectors, and nanoformulations of small-molecule drugs. Currently, most process development and lot-release methodologies are based on offline analytics, wherein test samples are sent to a remote lab to measure M_W and R_g post-process by SEC-MALS or FFF-MALS, inevitably leading to delays and increased costs.

This webcast introduces real-time MALS (RT-MALS), a novel process analytical technology that offers a first look at key quality attributes directly in the process stream. With RT-MALS, M_W and R_g are measured to enable monitoring and control of the process according to actual product parameters, not just process parameters. RT-MALS can determine if an end point has been attained and the process is complete, or if the product deviates from acceptable criteria and the process must be terminated. In process development scenarios, RT-MALS provides immediate feedback on the impact of varying process parameters. This webcast will review the technology of RT-MALS, benefits and applications, and will feature case studies.

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Characterization of nanotherapeutics by dynamic light scattering

Join us for a webinar on April 21 at 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST

Drug molecules that are highly effective for treatment, are often not suitable for standard delivery modalities due to hydrophobicity, degradation in the digestive tract or non-specific uptake. Nanoparticles may be designed to overcome these challenges and deliver drugs to their intended target with minimum loss or toxicity.

Simple and robust characterization of therapeutic nanoparticles is essential for the development process. Dynamic light scattering (DLS) is ideal for characterizing sub-micron particles when size and size distributions must be measured quickly, with little available material, and when the specific optical properties of the particles are not well known. PALS analysis determines the particle’s zeta potential, which is essential in reducing toxicity and targeting the desired organ.

This webinar consists of three contiguous segments—presented by three speakers—addressing the fundamentals of DLS and how it is used to characterize drug-delivery nanoparticles

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Recent Webinars

Previous webinars may be viewed in our Webinar Library. The following recent webinars are now available:

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