Upcoming Live Webinars
A Breakthrough in Process Analytical Technology for
Nanoparticles, Biopharmaceuticals and Polymers
Join us for a webinar on February 26 at 8:00 AM PST | 11:00 AM EST | 17:00 CET
Multi-angle light scattering (MALS) is primarily used with size-exclusion chromatography (SEC) or field-flow fractionation (FFF) to characterize macromolecules and nanoparticles in solution. SEC-MALS and FFF-MALS determine distributions of molecular weight (MW) and size (rms radius, Rg), which are key attributes determining the quality of advanced pharmaceuticals and biopharmaceuticals such as monoclonal antibodies, vaccines, gene vectors, and nanoformulations of small-molecule drugs. Currently, most process development and lot-release methodologies are based on offline analytics, wherein test samples are sent to a remote lab to measure MW and Rg post-process by SEC-MALS or FFF-MALS, inevitably leading to delays and increased costs.
This webcast introduces real-time MALS (RT-MALS), a novel process analytical technology that offers a first look at key quality attributes directly in the process stream. With RT-MALS, MW and Rg are measured to enable monitoring and control of the process according to actual product parameters, not just process parameters. RT-MALS can determine if an end point has been attained and the process is complete, or if the product deviates from acceptable criteria and the process must be terminated. In process development scenarios, RT-MALS provides immediate feedback on the impact of varying process parameters. This webcast will review the technology of RT-MALS, benefits and applications, and will feature case studies.
Characterization of nanotherapeutics by dynamic light scattering
Join us for a webinar on April 21 at 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST
Drug molecules that are highly effective for treatment, are often not suitable for standard delivery modalities due to hydrophobicity, degradation in the digestive tract or non-specific uptake. Nanoparticles may be designed to overcome these challenges and deliver drugs to their intended target with minimum loss or toxicity.
Simple and robust characterization of therapeutic nanoparticles is essential for the development process. Dynamic light scattering (DLS) is ideal for characterizing sub-micron particles when size and size distributions must be measured quickly, with little available material, and when the specific optical properties of the particles are not well known. PALS analysis determines the particle’s zeta potential, which is essential in reducing toxicity and targeting the desired organ.
This webinar consists of three contiguous segments—presented by three speakers—addressing the fundamentals of DLS and how it is used to characterize drug-delivery nanoparticles
Previous webinars may be viewed in our Webinar Library. The following recent webinars are now available:
Judith Kuntsche, Ph.D., and Christoph Johann, Ph.D.
January 28, 2020
Pernille Harris, Ph.D., and Esben Thormann, Ph.D., Denmark Technical University
December 10, 2019
Chris Deng, Ph.D., Wyatt Technology
November 14, 2019
Wolfgang Friess, Ph.D., Department of Pharmacy, Ludwig-Maximilians-Universitaet Muenchen
October 15, 2019
Andrew Lyon, Ph.D., Chapman University and Jason Lin, Ph.D., Wyatt Technology
September 17, 2019
The Versatility of High-Throughput Dynamic Light Scattering in Protein Characterization and Formulation Development
Katherine Bowers, Ph.D., Fujifilm Diosynth Biotechnologies
August 20, 2019
Judit Puskas, Ph.D., Ohio State University (OSU)
July 30, 2019
Jason Todd and Gavin Smith, SGS Polymer Solutions
June 18, 2019
Structural Characterization of Biopolymers by Analytical Separation Techniques with Advanced Detectors
Stepan Podzimek, Ph.D., Polymer Chemistry Department, University of Pardubice
May 9, 2019
Daniel Some, Ph.D., Wyatt Technology
April 9 & 16, 2019 and May 30, 2019
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