Upcoming Live Webinars

An Orthogonal Approach for Comprehensive AAV Characterization

Speakers: Ben Draper, Ph.D. (MegaDalton Solutions) and Sophia Kenrick, Ph.D. (Waters | Wyatt Technology)

Join us for a webinar on Thursday, May 30th at 8:00 AM PDT | 11:00 AM EDT | 17:00 CET

As the field of gene therapy progresses, processes to produce this life-changing therapy may introduce impurities that can significantly impact its performance and quality. Notably, empty AAV capsids represent a critical product-related impurity, necessitating accurate analytical methods to measure their levels. Our webinar will delve into the development and optimization of a size exclusion chromatography with UV and multiangle light scattering (SEC-MALS). We will also explore the full-to-empty ratio as well as the quantification of partials using charge detection mass spectrometry (CDMS). Join us to learn more about how SEC-MALS and CDMS can revolutionize analytical development and quality control testing. Additionally, discover how the standard AAV Method Implementation and Training Service, as well as SOP Guidance Manual, can facilitate the adoption of advanced technology as a platform method for AAV development and production.

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Insights into mRNA Lipid Nanoparticle Polydispersity and Shape of Using Quantitative Solution Biophysics

Speaker: Kushol Gupta, Ph.D. (University of Pennsylvania)

Join us for a webinar on Thursday, June 20th at 8:00 AM PDT | 11:00 AM EDT | 17:00 CET

Lipid nanoparticles (LNPs) are crucial for RNA therapeutics, notably after the success of Patisiran and COVID-19 mRNA vaccines. LNPs need precise design for effective clinical use, but the understanding on mixing methods influences the LNP structure and biological activity is limited.

This study addresses this gap by comparing standard and advanced characterization methods including multi-wavelength analytical ultracentrifugation (MWL-AUC), multi-angle light scattering (MALS), and synchrotron size-exclusion chromatography small-angle X-ray scattering (SEC-SAXS) with singular-value decomposition methods (SVD). We will present the strengths and weaknesses of each approach and showcase the increased detail newer advanced methods provide by comparing LNP formulations made using two common small-scale production methods: microfluidic rapid mixing and bulk mixing. The characterization techniques employed here can enhance our understanding of LNP structure-function relationships and enable researchers to define their RNA LNP products more precisely, which can improve LNP quality and potentially accelerate pharmaceutical development.

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Enhanced LNP quality assessment during Research and Development by DLS/SLS/ELS with the DynaPro ZetaStar Instrument

Speaker: David Golonka, Ph.D. (Waters | Wyatt Technology)

Join us for a webinar on Tuesday, June 25th at 6:00 AM PDT | 9:00 AM EDT | 15:00 PM CET

Size, Polydispersity, Particle concentration and Zeta potential are crucial parameters for understanding the quality of LNP samples. The DynaPro ZetaStar instrument obtains all this critical quality attributes for you in mere seconds which makes it the perfect analytical equipment for evaluating LNP characteristics. In this webinar, we will showcase how the ZetaStar instrument can be utilized in Research and Development for better understanding how formulation, solvent conditions, storage, and stress can alter the properties of LNP.

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Molecular structure of lignin by size exclusion chromatography with advanced detection

Speakers: Antje Potthast, Ph.D. (University of Vienna) and Stepan Podzimek, Ph.D. (Waters | Wyatt Technology)

Join us for a webinar on Tuesday, July 2th at 6:00 AM PDT | 9:00 AM EDT | 15:00 PM CET

Lignin is the world’s most abundant and underutilized source of aromatic biopolymer, produced in vast quantities through various industrial conversion processes. Its molecular structure is very complex with varying characteristic features like functional groups, linkage type, or degree of condensation after industrial isolation. One of the most important characteristics for studies on the application of lignin is its molar mass distribution which will be the focus of this webinar.

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Recent Webinars

Previous webinars may be viewed in our Webinar Library. The following recent webinars are now available:

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