Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

Researchers at the Yale University School of Medicine have identified the cellular prion protein as an amyloid-β oligomer receptor. Amyloid-β peptides are contained within the insoluble plaque which is a hallmark of Alzheimer's disease. The molecular weight of the oligomerized human Aβ42 was determined by using SEC-UV/LS/RI which included a DAWN EOS multi-angle light scattering detector and Optilab rEX refractometer.

Laurén, J.; Gimbel, D. A.; Nygaard, H. B.; Gilbert, J. W.; Strittmatter, S. M. Nature  2009, 457, 1128-1132. DOI: 10.1038/nature07761