AN1607: Kinase Fragment Oligomerization

Kinase Protein

Kinase fragments lacking the purported oligomerization domain are shown by SEC-MALS to dimerize. Reliance on column calibration by globular proteins would have lead to the deduction of kinase trimers or tetramers.

This note describes the analysis of a kinase fragment lacking its association domain in order to determine its oligomeric state in solution.