AN5006: Probing the aggregation rate of a Tau protein with DLS and SLS

In this work, batch dynamic and static light scattering in the DynaPro^® Plate Reader are used to investigate the aggregation of tau proteins, which have been observed to form neurofibrillary tangles in patients suffering from neurodegenerative diseases. Light scattering provides quick and easy-to-use methods to 1) screen starting materials, 2) measure aggregation rate on the nanometer scale, and 3) probe size distributions for greater insights into aggregation mechanism.