AN7601: Time-resolved Fibrin Network Formation by MALS and SAXS

Fibrin Network

Small-angle X-ray scattering (SAXS) is a powerful technique that measures <Rg2>z at much shorter length scales than does MALS. MALS and SAXS are therefore complementary techniques for determining valuable structural information, especially when applied to evolving samples.

This application note describes measurements made using a stopped-flow MALS-SAXS set-up that was implemented at the SWING beamline of the SOLEIL Synchrotron near Paris, France. The apparatus was developed for the study of the formation of fibrin networks following enzymatic activation of fibrinogen molecules.