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AN8004: Coupling MALS with preparative ionic-exchange (pIEX) for structural biology applications

Ion-exchange chromatography is a common intermediate step in a protein purification protocol. Adding a DAWN or miniDAWN multi-angle light scattering (MALS) detector in-line with FPLC and preparative ion-exchange chromatography (pIEX-MALS) allows absolute molar mass determination of the eluting fractions in the course of the run, providing immediate identification of pure fractions, for optimal pooling with minimal time and effort.


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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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