Characterizing Protein-Protein Interactions via Static Light Scattering: Nonspecific Interactions
In biotechnology applications, fine-tuning self-virial coefficients A2 (SVC) and cross-virial coefficients A11 (CVC) by adjusting pH, ionic strength, and concentrations of various excipients in the buffer can help set optimal conditions for stability, purification, and crystallization.
Reprinted from American Biotechnology Laboratory, 27(2): 16-20, ©2009