Conformation of Trimeric Form of Migration Inhibitory Factor (MIF)

Migration Inhibitory Factor

Migration inhibitory factor (MIF) was first discovered in the 1960’s as a T-cell product that inhibits the random migration of macrophages and is implicated in delayed-type hypersensitivity reactions. Since then it has been discovered that MIFs can act as a pituitary product that modulates systematic inflammatory responses and may play a role in mediating septic shock.