RT-MALS: Downstream PAT for Biologics, Vaccines and Gene Vectors
Presented by: Dan Some, Ph.D., Wyatt Technology
Presented Live: November 16, 2021
Rapid process development and scale-up of novel complex drugs requires advanced PAT tools, capable of providing timely feedback on product attributes. Real-time multi-angle light scattering (RT-MALS) determines key biophysical product attributes, including molar mass, particle size and particle concentration. These attributes are further indicative of quality attributes such as aggregation, identity or titer, and may be used for optimized process control as well as quality monitoring.
This webcast will review the principles, capabilities and limitations of RT-MALS, and then present case studies covering downstream processing (DSP) of proteins, polysaccharides, viruses and lipid nanoparticles.
