Solutions for Lipid Nanoparticle (LNP) Characterization

Wyatt Technology™ provides a full spectrum of lipid nanoparticle (LNP) characterization solutions, from LNP formulation screening to detailed analysis and quality control. Our light scattering techniques are simple to operate and enhance productivity, while directly addressing the core critical quality attributes.

Continue reading to learn about Wyatt’s solutions to industry and regulatory needs for LNP characterization.​

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Solutions to fit your workflow​​​

LNP formulation screening
LNP surface charge
Detailed characterization
Quality control

High-throughput LNP formulation screening​​

  • High-throughput
  • Size
  • Polydispersity
  • Particle concentration
  • Degradation

The DynaPro™ DLS/SLS Plate Reader combines dynamic and static light scattering in industry- standard microwell plates. In one day, it collects data that would otherwise take weeks. Its flexible plate format integrates with any liquid handling system. Even with a few samples, the DynaPro Plate Reader instrument frees up time for data analysis and interpretation.​​

LNP surface charge characterization​​​

  • Zeta potential
  • Size
  • Polydispersity
  • Particle concentration
  • Colloidal stability

Characterize the zeta potential of your LNPs and optimize your ionizable lipid selection and formulation with the DynaPro™ ZetaStar™ DLS/SLS/ELS instrument. Obtain simultaneous size, polydispersity, and zeta potential measurements in one minute. Boost your productivity further through automation by integrating the ZetaStar instrument with the Waters Arc™ HPLC pump and autosampler.​

Unprecedented detailed characterization​​​​

  • High-res size distribution
  • Payload distribution
  • Nucleic acid number
  • Encapsulation efficiency
  • mRNA characterization
  • Quantitative polydispersity

Obtain unprecedented, detailed analysis of your LNPs with the DAWN™ Multi-Angle Light Scattering (MALS) instrument coupled to a separation technique. This combination offers automatable, high-precision, and simultaneous quantification of LNP CQAs. Obtain high- resolution insights into lipid and mRNA subcomponents and how these payloads are distributed across the particles within the sample, all in a single experiment.

QC-ready solutions

  • Audit trail
  • Data management
  • User management
  • Electronic signature
  • IQ/OQ

For customers working in a quality control environment, it is essential that software complies with FDA regulations. Wyatt Technology Corporation has designed its software products from the ground up to meet the stringent requirements of the 21 CFR Part 11 standard. Developed under a formal quality system, the software includes comprehensive audit trails, robust data management, and thorough IQ/OQ documentation and procedures.

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Contact info:

Wyatt Technology LLC
6330 Hollister Ave
Santa Barbara, CA 93117 USA

Phone: +1 (805) 681-9009