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To Absolute Molar Mass and Beyond: Essential Polymer Characterization with Multi-Angle Light Scattering
Presented by Dr. Jeffrey Ahlgren, Senior Applications Scientist
Thursday, April 13, 2017
Characterization techniques based on multi-angle light scattering with size-exclusion chromatography (SEC-MALS) address many of the key analytical challenges in the modern polymer laboratory, including the absolute determination of molecular weight distributions and moments, branching ratios and copolymer composition/molecular weight distributions. This seminar will review light scattering technology, instrumentation and applications to polymer research and development. Select examples will illustrate how SEC-MALS overcomes the limitations of single-detector GPC, facilitating rapid and effective characterization of a wide variety of polymers including polyacrylamides, acrylic copolymers, nylons, styrenes and more. Advanced applications include high-molar-mass branched polymers and fluorescent polymers. Case studies will be presented to illustrate failures of standard SEC-MALS and their solutions via field-flow fractionation (FFF-MALS) and long-wavelength MALS with fluorescence blocking filters. The supplemental roles of Dynamic Light Scattering (DLS) and Viscometry will also be explored.
Place: Walter Library, University of Minnesota, Minneapolis, MN
Beyond Aggregates: Light Scattering Tools for Biophysical Characterization
Presented by Dr. Sophia Kenrick, Senior Applications Scientist
Monday, May 1, 2017 | Rancho Santa Fe, San Diego Marriott Marquis and Marina | 9:30 AM
Explore Wyatt’s powerful suite of light scattering techniques for biophysical characterization in the pursuit of efficacious biotherapeutics. Multi-angle light scattering (MALS) and dynamic light scattering (DLS) can be applied to all facets of development, from early candidate selection through scale-up, formulation, final process development, and regulatory filing, including comparability studies for biosimilars. Critical attributes, such as molar mass, aggregate content, degree of conjugation, thermal and colloidal stability, are efficiently and robustly quantified with light scattering techniques. This seminar will review light scattering theory, technology, and instrumentation, then present select examples illustrating how Wyatt's light scattering solutions facilitate rapid and effective development of biotherapeutics.
Visit us at Booth #403
Place: San Diego Marriott Marquis and Marina, San Diego, CA
Learn More and Register Here
Biopharma Separations Workshop Series
Large molecule characterization can be vast and overwhelming, with always more complex products being developed and increased quality requirements and regulations. Waters Corporation and Wyatt Technology Europe join together for a BioSeparations Workshop Series, to share with you insights on complementary technologies that are being used to overcome the challenges of large molecule analysis.
Join us for one of our one-day workshops to:
Discover µSEC-MALS for protein and polymer analysis
Waters and Wyatt technologies combine the high speed, high resolution, and low sample consumption of ACQUITY UP-SEC separations with optimized online multi-angle light scattering analysis. MALS is the recognized, indispensable method for obtaining absolute molecular weight and size, independently of column retention time.
Evaluate how multi-dimensional UPLC can help your lab resolve complex separations
By combining orthogonal techniques, increase assay robustness and throughput and convert salt buffer based methods into Mass Spectrometry friendly separations.
Learn how to develop and transfer more efficient peptide mapping separations
See how empowering your assay with mass detection, using ACQUITY QDa.Right from your Waters LC platform, access to oxidized or deamidated peptide monitoring.
Experiment the µSEC-MALS platform and the Peptide Mapping applications
with QDa Mass Detector during practical workshop sessions.
Workshops will take place in Germany, Belgium, The Netherlands and Switzerland. Registration is free of charge but space is limited. Register online now!