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High-Throughput or Well-Characterized? Light Scattering Tools for Rapid Screening and Deep Characterization of Therapeutic Nanoparticles
Presented by Dr. John Champagne, Senior Applications Scientist
Sunday, July 16, 2017 | 9:00 AM
Light scattering addresses many key analytical challenges in drug nanoparticle R&D, including accurate size distributions, conformation, payload and formulation. We review light scattering fundamentals, then present examples illustrating how Wyatt's unique light scattering instrumentation facilitates rapid and effective development of controlled release vehicles including liposomes, VLPs, polymer-encapsulated nanoparticles and nanogels.
Place: Room Beacon F, The Sheraton Boston Hotel, Boston, MA
Analyzing Protein Molecular Weight with SEC-MALS
Presented by Eric Seymour, Applications Scientist
Wednesday, July 19, 2017 | Adams Room, 3rd Floor, Loews Hotel in Philadelphia, PA | 12:00 PM - Light Lunch Provided
Molar mass is among the most important properties of a protein. Size exclusion chromatography is a well-established technique for protein characterization, often used to estimate molar mass. However, while SEC allows us to isolate protein aggregates and fragments, molar mass determined from column calibration is not always accurate. This seminar will explain how coupling multi-angle light scattering with SEC enables the determination of absolute molar mass without the need for reference standards. SEC-MALS works for glycoproteins, PEGylated proteins, and hydrophobic proteins that are not compatible with the traditional column calibration approach. Other case studies include ADCs, detection and quantification of aggregates, advantages of UPLC-SEC-MALS, and at-line process monitoring.
Visit us at our Booth!
Place: Loews Hotel, Philadelphia, PA
Learn More and Register Here
High-Throughput Light Scattering Tools for Characterizing and Formulating Macromolecules and Nanoparticles
Presented by Julia Deuel, Applications Scientist
Tuesday, August 22, 2017 | 9:30 AM | Westin Copley Place, Boston, MA
From aggregates to conjugates, peptides to polysaccharides, light scattering detectors provide a comprehensive suite of biophysical characterization tools. The light scattering toolkit determines molar mass, size, charge, interactions, and conjugation of macromolecules and nanoparticles. This seminar presents an overview of the instrumentation and example applications, focusing on µSEC-MALS-DLS, and HT-DLS.
Visit us at our Booth #106
Place: Westin Copley Place, Boston, MA
Learn More and Register Here
Biopharma Separations Workshop Series
Large molecule characterization can be vast and overwhelming, with always more complex products being developed and increased quality requirements and regulations. Waters Corporation and Wyatt Technology Europe join together for a BioSeparations Workshop Series, to share with you insights on complementary technologies that are being used to overcome the challenges of large molecule analysis.
Join us for one of our one-day workshops to:
Discover µSEC-MALS for protein and polymer analysis
Waters and Wyatt technologies combine the high speed, high resolution, and low sample consumption of ACQUITY UP-SEC separations with optimized online multi-angle light scattering analysis. MALS is the recognized, indispensable method for obtaining absolute molecular weight and size, independently of column retention time.
Evaluate how multi-dimensional UPLC can help your lab resolve complex separations
By combining orthogonal techniques, increase assay robustness and throughput and convert salt buffer based methods into Mass Spectrometry friendly separations.
Learn how to develop and transfer more efficient peptide mapping separations
See how empowering your assay with mass detection, using ACQUITY QDa.Right from your Waters LC platform, access to oxidized or deamidated peptide monitoring.
Experiment the µSEC-MALS platform and the Peptide Mapping applications
with QDa Mass Detector during practical workshop sessions.
Workshops will take place in Germany, Belgium, The Netherlands and Switzerland. Registration is free of charge but space is limited. Register online now!