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  • Analytical and Biophysical Characterization of Biotherapeutics: An Educational Workshop

    Biologic drugs have steadily risen on the list of top pharmaceuticals in the world. Analysis of these molecules is challenging and requires utilization of complementary analytical and biophysical techniques. Waters Corporation invites you to to learn about, share and discuss these tools, at free technical workshops in Milford, Massachussetts and Parsippany, New Jersey. Wyatt scientists will be presenting "Light Scattering Solutions for Biotherapeutic Characterization."

    Register for the Milford event, February 28, 2017.

    Register for the Parsippany event, March 2, 2017.


    GGPF 2017

    To Absolute Molar Mass and Beyond: Essential Polymer Characterization with Multi-Angle Light Scattering

    Presented by Dr. Jeffrey Ahlgren, Senior Applications Scientist
    Monday, March 13, 2017

    Characterization techniques based on multi-angle light scattering with size-exclusion chromatography (SEC-MALS) address many of the key analytical challenges in the modern polymer laboratory, including the absolute determination of molecular weight distributions and moments, branching ratios and copolymer composition/molecular weight distributions. This seminar will review light scattering technology, instrumentation and applications to polymer research and development. Select examples will illustrate how SEC-MALS overcomes the limitations of single-detector GPC, facilitating rapid and effective characterization of a wide variety of polymers including polyacrylamides, acrylic copolymers, nylons, styrenes and more. Advanced applications include high-molar-mass branched polymers and fluorescent polymers. Case studies will be presented to illustrate failures of standard SEC-MALS and their solutions via field-flow fractionation (FFF-MALS) and long-wavelength MALS with fluorescence blocking filters. The supplemental roles of Dynamic Light Scattering (DLS) and Viscometry will also be explored.

    Exhibitor RibbonVisit our Booth!

    Place: Michael's at Shoreline Mountain View, CA
    For more info and to Register: Golden Gate Polymer Forum Symposium on Polymer Characterization


    ACS 2017

    Advances in Asymmetric Flow Field Flow Fractionation (AF4) combined with MALS in the characterization of polymers in solution

    Presented by Dr. Jeffrey Ahlgren, Senior Applications Scientist
    Monday, April 3, 2017 | Room 120, Moscone Center | 1:30 PM | Industrial Innovations in Polymer Chemistry Symposium

    Applications in Asymmetric Flow Field Flow Fractionation (AF4) have been growing in number since its commercialization approximately 15 years ago. When coupled with online detectors such as multi-angle liight scattering detectors (MALS) and PALS (phase analysis light scattering detectors), molar mass distributions, size distributions, and even charge distributions can now be measured. AF4 can help confirm results determined by classical techniques such as SEC-MALS, and in cases of heavily branched material that becomes entangled in SEC packing material, fractionation by AF4 can result in improved size distribution analysis due to the nature of the fractionation method. Innovations such as hollow fibers have been developed to reduce sample and solvent requirements without loss of signal sensitivity. For sample types prone to entanglement or significant aggregation resulting from sample concentration during focusing steps, specialized channels such as the frit inlet channel have been developed to permit fractionation of these samples without a focusing step that typically is used during FFF methods. Examples of samples which do not fractionate well by SEC but were successfully fractionationated by FFF will be presented.

    Exhibitor RibbonVisit us at Booth #605

    Place: Moscone Convention Center, San Francisco, CA
    Learn More and Register Here


    ACS 2017

    Benefits of MALS, FFF and Viscometry in the characterization of polysaccharide molar mass, size, conformation and branching ratios

    Presented by Dr. Jeffrey Ahlgren, Senior Applications Scientist
    Thursday, April 6, 2017 | Room 130, Moscone Center | 9:20 AM | Frontiers in Glycoanalytics Symposium

    Complex carbohydrates such as cellulose can be characterized for molar mass, size, conformation and branching following fractionation by Asymmetric Flow Field Flow Fractionation (AF4) or Size Exclusion Chromatography (SEC) using multi-angle light scattering (MALS) and viscometry to measure these important physical characteristics. A multi-detector approach is beneficial for determining more than just molar mass distribution; characteristics such as intrinsic viscosity distributions and determination of conformation and branching characteristics can also be made. Examples of this type of multi-detector analysis will be presented to demonstrate the range and sensitivity that modern instrumentation is now capable of achieving with polysaccharides in solution when fractionated by SEC or FFF methods, including the use of hollow fiber technology with AF4. Recent improvements in on-line viscometry will also be discussed that enhance the sensitivity of detection and software improvements in data analysis to reduce issues from peak broadening and pump pulsations.

    Exhibitor RibbonVisit us at Booth #605

    Place: Moscone Convention Center, San Francisco, CA
    Learn More and Register Here


  • Biopharma Separations Workshop Series

    Large molecule characterization can be vast and overwhelming, with always more complex products being developed and increased quality requirements and regulations. Waters Corporation and Wyatt Technology Europe join together for a BioSeparations Workshop Series, to share with you insights on complementary technologies that are being used to overcome the challenges of large molecule analysis.

    Join us for one of our one-day workshops to:

    Discover µSEC-MALS for protein and polymer analysis

    Waters and Wyatt technologies combine the high speed, high resolution, and low sample consumption of ACQUITY UP-SEC separations with optimized online multi-angle light scattering analysis. MALS is the recognized, indispensable method for obtaining absolute molecular weight and size, independently of column retention time.

    Evaluate how multi-dimensional UPLC can help your lab resolve complex separations

    By combining orthogonal techniques, increase assay robustness and throughput and convert salt buffer based methods into Mass Spectrometry friendly separations.

    Learn how to develop and transfer more efficient peptide mapping separations

    See how empowering your assay with mass detection, using ACQUITY QDa.Right from your Waters LC platform, access to oxidized or deamidated peptide monitoring.

    Experiment the µSEC-MALS platform and the Peptide Mapping applications

    with QDa Mass Detector during practical workshop sessions.

    Workshops will take place in Germany, Belgium, The Netherlands and Switzerland. Registration is free of charge but space is limited. Register online now!


For additional information on all seminars, please contact This email address is being protected from spambots. You need JavaScript enabled to view it.



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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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