Wyatt Technology


  • Not sure which instruments and accessories you need to carry out any of the light scattering techniques we provide? Visit the Instrument Overview to find the right configuration, where we have listed each technique along with the primary instruments and associated accessories.

    If you know which type of instrument interests you, the categories below will help you compare models.



    Couple a DAWN, miniDAWN or μDAWN multi-angle light scattering (MALS) detector to SEC or FFF for reliable characterization of distributions of molar mass / molecular weight, size, conjugation and conformation of macromolecules, aggregates, fragments, conjugates, colloids, and nanoparticles.

    All measurements take place in solution, and are independent of inherently unreliable column calibration.



    DLS & ELS

    Dynamic light scattering (DLS) measures the hydrodynamic radius of proteins, aggregates, nanoparticles, vesicles, and more. The NanoStar uses standard microcuvette format and the DynaPro Plate Reader II high-throughput microwell plates.

    The Möbiuζ measures electrophoretic light scattering (ELS) and DLS simultaneously to determine zeta potential or molecular charge, automated by an autosampler or manually, under a wide range of solvents.




    Optilab differential refractive index (dRI) detectors are utilized primarily for on-line measurement of analyte concentration in SEC-MALS and FFF-MALS, and for determination of analyte dn/dc (refractive index increment), and the absolute refractive index (aRI) of solvents.

    Optilab dRI detectors serve as universal concentration detectors since no chromaphore or fluorophore is necessary. Required for Conjugation Analysis.




    The ViscoStar II on-line differential viscometer measures the intrinsic viscosity of polymers downstream of SEC. Differential viscometry is best combined with MALS and RI for analysis of polymer conformation and Mark-Houwink-Sakurada parameters.

    On its own, the ViscoStar can determination hydrodynamic radius, or may be utilized with the Universal Calibration technique to assess polymer molar mass / molecular weight over a wide range.

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    The Calypso II automated composition-gradient accessory and software are used in conjunction with a MALS detector (CG-MALS) to characterize biomolecular interactions, label-free and immobilization-free. CG-MALS determines equilibrium dissociation constants self- and hetero-association as well as more complex interactions.

    Also useful for automation of Zimm plots, dn/dc analysis, reaction kinetics and polymer interaction analyses.

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    Eclipse devices carry out field-flow fractionation (FFF) of macromolecules and nanoparticles ranging in size from 1 nm - 1000 nm, with no stationary phase, eliminating shear and non-ideal column packing interactions. Integrates with top-quality HPLC pumps and autosamplers.

    A wide selection of flat and hollow-fiber channels separates both soluble and colloidal components, from nanogram to milligram quantities.

  • columns, WyattQELS


    MALS Accessories

    These items add many capabilities and ease-of-use to your MALS measurements, from an embedded dynamic light scattering module to MALS-friendly SEC columns or even a batch conversion kit.



    DLS and ELS Accessories

    These accessories include quartz and disposable microcuvettes, sample filtration kits and other items helpful in dynamic light scattering and electrophoretic mobility measurements made in DynaPro or Möbiuζ instruments.

    Eclipse channels, FFF accessories


    FFF Accessories

    Find the right channels and membranes for your specific field-flow fractionation methods.

    RI Calibration Kit, accessories


    Miscellaneous Accessories

    These items are useful in a variety of light scattering setups, from keeping your solvents sterile to organizing your work space.

  • ASTRA 6, software



    Our comprehensive software solution for MALS and DLS analysis in chromatography, FFF or batch mode.

    ASTRA is included with each MALS, dRI and dVI detector. It is available in both standard and 21 CFR(11)-compliant versions, and offers additional modules for advanced capabilities, such as universal calibration (online viscometry), particle analysis or research database.

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    DYNAMICS 7, software



    Software for batch DLS, SLS and ELS measurements in the DynaPro and Möbiuζ instruments, included with each.

    DYNAMICS calculates size, size distributions, and derived parameters such as the melting temperature TM, the aggregation onset temperature Tonset and the concentration coefficient of diffusion kD.

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    CALYPSO, software



    Design, control, data acquisition and analysis of CG-MALS measurements for macromolecular interactions in solution.

    CALYPSO provides an unusually extensive set of interaction models covering self-association, hetero-association, and non-specific interactions with advanced modeling capabilities.

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    ECLIPSE, software



    Controls the Eclipse DualTec and AF4 Field-Flow Fractionation (FFF) systems via standard industry-wide packages such as ChemStation, OpenLAB, Chromeleon and LCsolution.

    Coupled with ASTRA for data collection and analysis, ECLIPSE provides users with a turn-key solution for macromolecular and nanoparticle characterization.

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  • customer support


    Customer Support

    When you purchase a new Wyatt instrument, you get more than a warranty contract - we are here to help with a friendly, expert staff of technicians and Ph.D. scientists who provide industry-benchmark training, technical and application assistance, instrument maintenance and more. 

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    on-site services


    On-Site Services

    Wyatt offers on-site installation and training services at your laboratory, tailored to your specific needs.

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    A complete compliance program including documentation and on-site validation for all Wyatt instruments. This includes IQ and OQ documents and kits, plus software modules for data traceability and authentication to meet FDA 21 CFR (11) requirements.

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    Contract Labs


    Contract Labs

    Need to characterize your samples by light scattering, but do not currently have the budget or manpower for your own instruments? Find a 3rd-party academic, government or commercial facility that offers contract analytical services using Wyatt instruments in your region.

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    Sample Analysis


    Sample Analysis

    Not ready to buy a Wyatt instrument but need the assistance of the foremost experts in light scattering analysis? Consider our analytical lab and consulting services in the areas of macromolecular and nanoparticle characterization, including SEC-MALS, FFF-MALS, CG-MALS, DLS and ELS.

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For essential macromolecular and nanoparticle characterization—The Solution is Light™

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ISO Certification


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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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