Wyatt Technology

ASTRA

ASTRA 6

Turn your data into results with the ultimate in light scattering software—ASTRA.

Included with every Wyatt MALS detector is ASTRA—the most powerful and versatile software available for the characterization of macromolecules and nanoparticles via multi-angle and dynamic light scattering.

Maximize your productivity via ASTRA's automated multi-sequence processing and HPLC integration. Take advantage of its integrated control of Agilent systems, or its support for Waters Empower sequences.

ASTRA offers a suite of basic and advanced analyses, including customized reports and an optional 21CFR(11)-compliant security and database package. It greatly simplifies MALS and DLS analysis, so you can quickly and accurately assess molar mass, size, conformation, conjugation and other essential physical parameters of macromolecules and nanoparticles. But we take you above and beyond: with each analysis, ASTRA provides the quantitative experimental uncertainties that transform mere numbers—into science.

Multi-detector Chromatography
Analyze molar mass, size and conformation using multi-detector chromatography
  • Report Editing

    HPLC Control

    ASTRA 7's integrated HPLC Control delivers a one-stop solution for SEC-MALS.
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    Surface Plot

    Unmatched Analysis

    Use the full power of your multi-core computer for fast, responsive data processing on Wyatt's patented analysis infrastructure.
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    EASI Table

    High-Throughput Processing

    Let your computer do the work. Process one file yourself, and let ASTRA take care of the rest.
    Read more...

     

    Browse this page to learn about the dozens of other capabilities and features in ASTRA, making it is the most powerful and versatile software available for the characterization of macromolecules and nanoparticles via multi-angle and dynamic light scattering.

  • HPLC Control

     
    Full digital synchronization between your HPLC system, Wyatt detectors and ASTRA 7:

    • Minimizes user errors
    • Runs SEC-MALS from a single, familiar environment
    • Saves you time and money

    ASTRA 7's HPLC control modules works with standard Agilent hardware including pumps, autosamplers, column ovens and UV/Vis detectors.*

    *Control of additional HPLC instruments coming soon

    HPLC Manager

    Integrated HPLC control

    Let ASTRA take control of your HPLC stack for effortless synchronization between injections and data collection. ASTRA 7 eliminates the need for separate HPLC and light scattering software. HPLC modules are listed together with Wyatt detectors in a common experiment configuration, and key parameters such as vial position, injection volume and flow rate specified in ASTRA's sequences.

    HPLC Manager

    HPLC Manager

    The HPLC Manager app controls and monitors HPLC modules including pumps, column ovens, UV detectors and autosamplers, right from the desktop. Included free with the HPLC Control module.

    HPLC Manager

  • High-Throughput Processing

    Rebuilt from the ground up to meet the needs of scientists working with large sets of data, ASTRA 6 has the tools you need to process and report on replicates. The new "One-to-Many" processing interface lets you focus on your goals, and leave the drudgery to the computer.


    EASI Table

    Everything you need at a glance.

    With the new EASI Table feature, you can quickly compare multiple data runs to assess compound stability and consistency. The table data can be easily exported in a variety of formats, or copied and pasted into your favorite word processing software.

    You can easily specify which data should be displayed in EASI Table, as well as the format and precision used to display the values. You can switch from percent to numerical uncertainties, or omit them entirely.

    EASI Table


    Sequence Processing

    Collect data while you sleep.

    Sequences are used to specify and control the automated collection of data. A sequence can be configured with a default experiment method, such that all samples are collected in the same fashion. Additionally, a different method can be specified for each sample, making it possible to collect different types of data for each sample (e.g., QELS collection on two out of ten runs), or perform post-collection maintenance, such as running the COMET flow cell cleaner, or moving the Orbit to recycle mode.

    Sequence

    In the samples view, it is possible to modify sample parameters on-the-fly, adding samples, changing collection times, or skipping samples.


    Let your computer do the work.

    ASTRA 6 allows you to process an experiment as you wish, then instruct the computer to apply the same settings and analysis steps on any number of additional data files. You can quickly and easily specify which elements of your 'source' experiment should be incorporated in the target experiments.

    Processing

    Once the processing is finished, your resulting data files are fully analyzed and ready to be reviewed.

  • Unmatched Analysis

    ASTRA Main Screen

    Building on over 20 years of light scattering research and development, ASTRA 6 includes a wide range of analysis features unrivaled in the marketplace. Designed to take full advantage of modern multicore computers, ASTRA 6 processes data at blazing speeds and with superior accuracy.

    Customizable Analysis

    Choose from one of the dozens of predefined analysis methods, or create your own.

    Research by definition means you are breaking new ground. While our existing analysis methods cover a wide range of applications, your specific research goals may lie outside these options. That's why we designed ASTRA to support customizable analysis methods so that you can decide which data processing features to use.

    Cutting Edge Technology

    Take advantage of Wyatt Technology's patented technologies.

    Wyatt Technology is committed to pushing macromolecular characterization to new levels. Consequently, we have a very strong program to develop intellectual property. Many of the algorithms in ASTRA are on the cutting edge of scientific analysis, and are either patented or have patents pending. ASTRA is protected by U.S. patent Numbers: 5,528,366; 6,411,383; 6,651,009; 6,774,994; 7,386,427; 7,911,594; German Patent Numbers: 694 33 615.7-08; 603 19 078.2-08; British Patents Based on European Application Numbers: EP 0 665 433; EP 1 510 807; Japanese Patent Numbers: 3,580,380; 4,439,211; 4,381,914; and other patents pending.

    Please contact Wyatt Technology if you wish to incorporate any ASTRA functionality into your own software.

    Molar Mass Determination

    Determine molar mass and size.

    Molar Mass via Light Scattering

    Light scattering stands alone in its ability to measure the molar mass of macromolecules in solution both accurately and quickly.
    Learn more


    Molar Mass via Conventional and Universal Calibration

    Build a bridge between legacy conventional and universal calibration results and modern, accurate light scattering analysis. Learn more

    Protein Conjugate and Copolymer Analysis

    Determine molar mass, size, and relative fractions.

    If you have an RI detector, a UV detector, and a light scattering instrument, you can directly measure the molar mass, size, and relative fractions of copolymers and protein conjugates. Learn more

    Particles and Number Density

    Determine size and number density with just a light scattering detector.

    It is possible to measure the size and number density of a sample with just a light scattering instrument. ASTRA supports several sophisticated models to determine the size of a macromolecule based solely on the angular variation in the light scattering intensity.
    Learn more

    Translational Diffusion and Hydrodynamic Radius

    Determine translational diffusion and hydrodynamic radius with dynamic light scattering.

    On-Line QELS

    With the support of a QELS instrument module, you can extend your data analysis to determine the translational diffusion and corresponding hydrodynamic radius of your samples. Learn more


    QELS batch Regularization and Cumulants

    Determine translational diffusion and corresponding hydrodynamic radius of your unfractionated samples. Learn more

    Viscometry

    Measure viscosity directly using the Wyatt ViscoStar II.

    ASTRA provides several analysis features that take advantage of viscosity data. Use these features to further quantify your macromolecules to determine Mark-Houwink-Sakurada terms, hydrodynamic radius, and more. Learn more

    Molecular Conformation

    Assess the shape of your molecules.

    The shape of molecules can be assessed from the molar mass and rms radius of the sample. Learn more

    Branching

    Determine polymer branching from light scattering, viscosity, or both.

    ASTRA includes sophisticated branching calculations to assess the branching characteristics of a polymer sample. Learn more

    Distributions

    Evaluate the distribution of components in a sample.

    Sample properties are determined for individual peaks in a chromatography run. ASTRA also supports visualizing these data in terms of the distribution of these measured quantities. This is extremely powerful when assessing how much of a sample falls with a particular range of molar mass or size. Learn more

    Second Virial Coefficient (A2) Measurements

    Determine macromolecule self-association behavior.

    The second virial coefficient (A2) is a measure of macromolecular self-association, and is one of the few parameters that can be used to predict the crystallization properties of a sample. ASTRA allows you to measure this important characteristic. Learn more

    dn/dc and UV extinction coefficient determination

    Measure the dn/dc and UV extinction coefficients for your novel samples.

    While dn/dc and UV extinction coefficients are documented for many existing compounds, they must be experimentally determined for novel samples. ASTRA provides analysis features to measure these critical sample characteristics. Learn more

    Band Broadening Correction

    Model and account for inter-detector mixing effects.

    While most analysis packages force you to live with the undesirable effects of passing a sample through a series of detectors. ASTRA's revolutionary band broadening correction accounts for these effects to give you most accurate results possible. Learn more

    Absorbance Correction

    Account for samples that absorb light.

    If a sample absorbs light at the MALS laser wavelength, molar mass calculations will be skewed due to less light reaching the scattering volume than expected. ASTRA uses the Forward Monitor detector signal available in all Wyatt MALS instruments to calculate the laser attenuation produced by sample absorption and correct the scattering signal levels. In this manner accurate molecular weights are ensured, even in the presence of absorbtion.

    Blank Subtraction

    Flatten out complicated FFF runs.

    Certain analysis techniques, such as FFF, cause large changes in refractive index and viscosity measurements as flow rates are modified during the run. This can make it difficult to properly analyze the file, as the RI and viscosity changes due to flow and pressure changes mask those caused by the sample. ASTRA provides a mechanism to subtract a data collection run without sample (a 'blank') from a sample run to reveal the sample-specific signal changes. Learn more

    Error Analysis

    ASTRA provides a rock-solid scientific foundation for your results.

    Wyatt Technology software is written by scientists for scientists. ASTRA was designed from the ground up to properly compute and propagate uncertainties to ensure our results are publication-quality. Learn more

  • State of the Art Reporting

    Take control of your analysis reporting with ASTRA 6's custom reporting system. With just a few mouse clicks, adjust which data to display and how it should be formatted. Add your own logo, incorporate some personal notes, or just pare the default reports to focus on what you care about.

    Report Designer

    Customizable Logo and Summary

    Personalize your reports.

    Report Options

    In addition to the numerical and content selections provided in the Report Designer, ASTRA 6 allows you to specify a logo image, and where it should be displayed. You can specify the title as well as additional summary information or notes that will appear on the report.

    Personalized Data Selection

    Choose your data. Choose your formatting.
    Show your achievements.

    Report Data Options

    Control the content and presentation of your reports with a few mouse clicks. Any bit of data generated during analysis is now available for you to incorporate into your report, with just a click of the mouse.

    Full Numerical Formatting

    Choose your display style and precision.

    Click on a result, and ASTRA 6 presents a simple, intuitive interface for controlling the numerical precision and display format of the result. Quickly and easily change results from fixed point to scientific notation, increase or decrease the number of significant digits to display, and determine if you wish uncertainties to be displayed as numerical values or percentages.

    Formatting Results

  • Wyatt Software System Requirements

    For optimal performance, ASTRA requires a PC with these minimal specifications:

    • Intel i5 processor
    • Display with 1280-by-768 resolution
    • Support for DirectX 9 graphics
    • 4 GB of RAM; 8GB if additional software is to run simultaneously on the same PC, e.g. HPLC software, or SQL Server for ASTRA/DYNAMICS Security Pack
    • 1 GB of available disk space for installation
    • 1 Ethernet port
    • Supported operating system mentioned below
    • DVD drive for installation

    Operating System

    Windows 7 Compatibility

    ASTRA will run on the following operating systems:

    • Microsoft Windows 10 Pro/Enterprise
    • Microsoft Windows 8 Pro/Enterprise
    • Microsoft Windows 7 Professional/Enterprise/Ultimate

    ASTRA has been tested extensively with English versions of the Windows operating system. We do not guarantee absolute compatibility with all other language versions but in our experience we have seen almost no issues.

    Microsoft Windows Home Editions are not supported for ASTRA data collection or Security Pack mode, though they may be used for analysis of data files.


    Important notes for ASTRA functionality

    • Legacy QELS detectors: The driver used to support the external WyattQELS (used with the DAWN EOS and miniDAWN TriStar) is not compatible with 64-bit Windows operating systems. You must use a 32-bit operating system to control this module.

   

For essential macromolecular and nanoparticle characterization—The Solution is Light™

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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.



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