Building on over 20 years of light scattering research and development, ASTRA 6 includes a wide range of analysis features unrivaled in the marketplace. Designed to take full advantage of modern multicore computers, ASTRA 6 processes data at blazing speeds and with superior accuracy.
Choose from one of the dozens of predefined analysis methods, or create your own.
Research by definition means you are breaking new ground. While our existing analysis methods cover a wide range of applications, your specific research goals may lie outside these options. That's why we designed ASTRA to support customizable analysis methods so that you can decide which data processing features to use.
Cutting Edge Technology
Take advantage of Wyatt Technology's patented technologies.
Wyatt Technology is committed to pushing macromolecular characterization to new levels. Consequently, we have a very strong program to develop intellectual property. Many of the algorithms in ASTRA are on the cutting edge of scientific analysis, and are either patented or have patents pending. ASTRA is protected by U.S. patent Numbers: 5,528,366; 6,411,383; 6,651,009; 6,774,994; 7,386,427; 7,911,594; German Patent Numbers: 694 33 615.7-08; 603 19 078.2-08; British Patents Based on European Application Numbers: EP 0 665 433; EP 1 510 807; Japanese Patent Numbers: 3,580,380; 4,439,211; 4,381,914; and other patents pending.
Please contact Wyatt Technology if you wish to incorporate any ASTRA functionality into your own software.
Molar Mass Determination
Determine molar mass and size.
Molar Mass via Light Scattering
Light scattering stands alone in its ability to measure the molar mass of macromolecules in solution both accurately and quickly.
Molar Mass via Conventional and Universal Calibration
Build a bridge between legacy conventional and universal calibration results and modern, accurate light scattering analysis. Learn more…
Protein Conjugate and Copolymer Analysis
Determine molar mass, size, and relative fractions.
If you have an RI detector, a UV detector, and a light scattering instrument, you can directly measure the molar mass, size, and relative fractions of copolymers and protein conjugates. Learn more…
Particles and Number Density
Determine size and number density with just a light scattering detector.
It is possible to measure the size and number density of a sample with just a light scattering instrument. ASTRA supports several sophisticated models to determine the size of a macromolecule based solely on the angular variation in the light scattering intensity.
Translational Diffusion and Hydrodynamic Radius
Determine translational diffusion and hydrodynamic radius with dynamic light scattering.
With the support of a QELS instrument module, you can extend your data analysis to determine the translational diffusion and corresponding hydrodynamic radius of your samples. Learn more…
QELS batch Regularization and Cumulants
Determine translational diffusion and corresponding hydrodynamic radius of your unfractionated samples. Learn more…
Measure viscosity directly using the Wyatt ViscoStar II.
ASTRA provides several analysis features that take advantage of viscosity data. Use these features to further quantify your macromolecules to determine Mark-Houwink-Sakurada terms, hydrodynamic radius, and more. Learn more…
Assess the shape of your molecules.
The shape of molecules can be assessed from the molar mass and rms radius of the sample. Learn more…
Determine polymer branching from light scattering, viscosity, or both.
ASTRA includes sophisticated branching calculations to assess the branching characteristics of a polymer sample. Learn more…
Evaluate the distribution of components in a sample.
Sample properties are determined for individual peaks in a chromatography run. ASTRA also supports visualizing these data in terms of the distribution of these measured quantities. This is extremely powerful when assessing how much of a sample falls with a particular range of molar mass or size. Learn more…
Second Virial Coefficient (A2) Measurements
Determine macromolecule self-association behavior.
The second virial coefficient (A2) is a measure of macromolecular self-association, and is one of the few parameters that can be used to predict the crystallization properties of a sample. ASTRA allows you to measure this important characteristic. Learn more…
dn/dc and UV extinction coefficient determination
Measure the dn/dc and UV extinction coefficients for your novel samples.
While dn/dc and UV extinction coefficients are documented for many existing compounds, they must be experimentally determined for novel samples. ASTRA provides analysis features to measure these critical sample characteristics. Learn more…
Band Broadening Correction
Model and account for inter-detector mixing effects.
While most analysis packages force you to live with the undesirable effects of passing a sample through a series of detectors. ASTRA's revolutionary band broadening correction accounts for these effects to give you most accurate results possible. Learn more…
Account for samples that absorb light.
If a sample absorbs light at the MALS laser wavelength, molar mass calculations will be skewed due to less light reaching the scattering volume than expected. ASTRA uses the Forward Monitor detector signal available in all Wyatt MALS instruments to calculate the laser attenuation produced by sample absorption and correct the scattering signal levels. In this manner accurate molecular weights are ensured, even in the presence of absorbtion.
Flatten out complicated FFF runs.
Certain analysis techniques, such as FFF, cause large changes in refractive index and viscosity measurements as flow rates are modified during the run. This can make it difficult to properly analyze the file, as the RI and viscosity changes due to flow and pressure changes mask those caused by the sample. ASTRA provides a mechanism to subtract a data collection run without sample (a 'blank') from a sample run to reveal the sample-specific signal changes. Learn more…
ASTRA provides a rock-solid scientific foundation for your results.
Wyatt Technology software is written by scientists for scientists. ASTRA was designed from the ground up to properly compute and propagate uncertainties to ensure our results are publication-quality. Learn more…