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Wyatt Technology

Dynamic & Electrophoretic Light Scattering

 

  • DynaPro Plate Reader

    DynaPro Plate Reader II

    High-throughput, automated dynamic light scattering.

    The DynaPro Plate Reader II provides unparalleled levels of productivity and flexibility for the most demanding nanoparticle sizing and protein aggregation tasks such as biotherapeutic formulation, screening of promiscuous inhibitors, and optimization of protein crystallization conditions. Measurements are performed in situ with no fluid transfer. Select from industry-standard 96-, 384- or 1536-microwell plates.

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  • DynaPro NanoStar

    DynaPro NanoStar

    Traditional dynamic light scattering, just better.

    The DynaPro NanoStar operates in traditional microcuvette-based format to analyze sizes and size distributions of proteins, micelles, quantum dots, liposomes, and metallic nanoparticles. It uniquely combines two optimized 90° detections channels: one for DLS and one for static light scattering. Providing an extraordinary temperature range, the NanoStar performs robust, accurate measurements with as little as 1 µL of sample.

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  • Möbius

    Möbiuζ

    Automated electrophoretic mobility measurements of proteins and nanoparticles, in all types of solvents.

    The Möbiuζ connects to an autosampler to make reliable, reproducible, and non-destructive electrophoretic mobility measurements of macromolecules as small as 1 nm in radius, as well as micron-size nanoparticles. Versatile and sensitive, the Möbiuζ characterizes the mobility of fragile biomolecules non-destructively, at low applied voltage, or nanometer-sized inorganic nanoparticles at high applied voltage.

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Feature Comparison

Capabilities DynaPro
Plate Reader II
DynaPro
NanoStar
Möbiuζ
 
Measurements      
Nanoparticle Size Range (Rh, by DLS) 0.5 – 1000 nm 0.2 – 2500 nm 0.2 – 5000 nm (flow cell);
0.2 - 200 nm (dip cell, quartz cuvette);
0.2 – 250 nm (disposable cuvette)
Molar Mass Range by SLS N/A 300 Da – 1 MDa N/A
Sensitivity (lysozyme 14.4 kDa) 0.125 mg/mL 0.1 mg/mL 0.1 mg/mL
Electrophoretic Mobility Range N/A N/A no practical limit
Mobility Size Range N/A N/A 1 nm – 50 µm
Mobility Sensitivity N/A N/A 1 mg/mL lysozyme (flow cell);
5 mg/mL BSA (dip cell)
   
Fluidics      
Minimum Sample Volume 4 µL (1536-well plate) 1.25 µL (quartz cuvette),
4 µL (disposable cuvette)
170 µL (flow cell);
45 µL (quartz cuvette)
   
Optics      
Laser Wavelength 830 nm 658 nm 532 nm
Laser Power Control Programmable 10% – 100% Programmable 10% – 100% Programmable 10% / 100%
   
Sample Cell Options 96-, 384- or 1536-well microwell plates. Industry standard disposable (select from recommended list). 1 µL quartz cuvette,
4 & 45 µL disposable cuvettes
Mobility & DLS:
170 µL flow cell;
65 µL dip cell

DLS only:
45 µL quartz cuvette;
100 µL disposable cuvette
   
Temperature Control 4 – 85°C -15 – +150°C 4 – 70°C

 

See Accessories for DLS & ELS

 

   

For essential macromolecular and nanoparticle characterization—The Solution is Light™

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ISO Certification

iso-certification

  ISO 9001:2008

   

 

Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.



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