Wyatt Technology

Live Webinars

Advances in High-Throughput Screening of Aggregation, Stability and Viscosity Utilizing Light Scattering in Microwell Plates

Join us for a webinar on October 26 at 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST

Aggregation and stability are important criteria for selecting biotherapeutic candidates for developability and optimizing their formulation. Screening of the broadest matrix of conditions and excipients enables true QbD, imparting confidence in the ultimate choice of candidates and formulations with which to move forward.

The primary biophysical techniques for characterizing aggregation and stability in a high-throughput, broad-matrix setting are based on light scattering. Dynamic light scattering (DLS) determines size and size distributions, while changes in apparent size and aggregation with temperature (Tm, Tagg) and concentration (kD) are indicative of conformational stability and colloidal stability, which in turn help predict propensity for aggregation. Turbidity and aggregation estimates are also obtained from the static light scattering information inherent in DLS measurements.

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Quickly Screen Peptides, Proteins and Nanoparticles for Size and Aggregation Using Advanced Methods

Join us for a webinar on November 14 at 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST

Dynamic Light Scattering (DLS) is the most widely employed technique for size and polydispersity measurement in protein, polymer, and nanoparticle research. Traditionally, DLS has been limited to measuring a single sample at one time in a cuvette, but the DLS Plate Reader from Wyatt breaks through this limitation by measuring entire well plates of samples at one time. This expanded measurement capacity combined with small volume requirement and flexible, custom experiment design enable analyses that were not previously possible.

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Previous webinars may be viewed in our Webinar Library. The following recent webinars are now available:

 

   

For essential macromolecular and nanoparticle characterization—The Solution is Light™

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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.



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