Conventional Size Exclusion Chromatography (SEC) relies on reference standards that do not accurately represent your molecules. Multi-Angle static Light Scattering (MALS) measures molar mass directly, independent of elution time, so you can have confidence in the values you report.
Field-Flow Fractionation (FFF) is a versatile separation technique that overcomes many of the limitations of analytical SEC. Combine with MALS and/or Dynamic Light Scattering (DLS) for absolute molar mass and size.
Composition-Gradient, Multi-Angle static Light Scattering (CG-MALS) is a powerful technique for characterizing a wide range of biomolecular interactions, label-free and immobilization-free. CG-MALS determines binding affinity, absolute stoichiometry, equilibrium and kinetics of simple or complex interactions.
Widely used in biochemistry, biotechnology and pharmaceutical development, Dynamic Light Scattering (DLS) is popular wherever the size and size distributions of macromolecules and nanoparticles need to be measured quickly and easily. Wyatt offers high-throughput, automated DLS as well as conventional formats.
Massively Parallel Phase Analysis Light Scattering (MP-PALS) improves over conventional Phase Analysis Light Scattering to determine electrophoretic mobility and charge with maximum sensitivity and minimal damage to fragile biomolecules.
Intrinsic Viscosity in conjunction with Size Exclusion Chromatography (SEC-IV) characterizes those classes of polymers that are incompatible with light scattering, and extends MALS conformational analysis to low molecular weight samples.