Wyatt Technology

Automation of Biologics Formulation Preparation and Stability Studies

 

Presented Live: April 9, 2015

Speakers: Dr. Daniel Some, Principal Scientist and Director of Marketing
and Dr. Russell Burge, Applications Scientist, Freeslate

This webinar presents Freeslate's Biologics Formulation System (BFS) which automates formulation preparation, screening and stability studies for the development of biotherapeutics. Designed in collaboration with leading pharmaceutical organizations, the BFS is an integrated workspace based on Freeslate’s laboratory robotics platform. The BFS greatly enhances productivity while exploring an expanded design space to determine the optimal formulation.

One of the key analytical tools integrated into the BFS is Wyatt's DynaPro Plate Reader II. The DynaPro employs dynamic light scattering (DLS) to characterize molecular size distributions in order to quantitatively assess aggregation, conformational changes, propensity for aggregation and viscosity. The DynaPro is one of several analytical instruments supported by the BFS.

In the presented case studies, the Freeslate BFS prepared and characterized an extended series of formulations, then applied a variety of stresses. Post stress, formulations were re-analyzed to assess stability. A significant reduction in scientist time was seen as compared to traditional manual operations, yet more formulations were tested than a typical study - producing greater confidence in an optimal final selection. DynaPro temperature ramps and aggregation data were central in this accomplishment.

Topics Covered

  • How laboratory automation can be applied to biologics formulation screening and stability studies, increasing productivity and broadening the formulation design space
  • The benefits of integrating formulation preparation and analytics into a single workflow
  • The unique capabilities of high-throughput dynamic light scattering for assessing biotherapeutic formulations and stability

 

  Webinar Q & A

 

 

   

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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.



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