Advanced analytics for proteins and biological nanoparticles

Waters | Wyatt Light Scattering Seminar Warsaw:
Advanced analytics for proteins and biological nanoparticles

Location: Hotel Verte, ul. Podwale 3a, 00-252 Warszawa
Date: 27th February 2025

Light scattering is a powerful technique to conveniently assess several critical quality attributes of nanoparticles, therapeutic proteins, viral vectors, or different nano-drug delivery systems such as lipid nanoparticles (LNPs). Questions of identity, purity, quantity, and payload content can be answered by means of multi-angle light scattering (MALS), dynamic light scattering (DLS), and electrophoretic light scattering (ELS). Making use of Wyatt’s advanced methods clears the last doubts about your sample’s quality.

Join Wyatt for a day of learning about the characterization of proteins, oligomers, and even complex protein conjugates like ADCs. Find out more about multi-attribute quantification of mRNA-lipid nanoparticle therapeutics: from size to particle concentration and size-based nucleic acid payload distribution and dive into application-driven discussions. Take a refresher on the characterization of LNP, AAVs, and lentiviruses using light scattering. Discover what’s new, meet your peers, and spend some quality time with Wyatt staff. Learn the capabilities of light scattering and how these methods can complement your existing suite of analytical tools.

Topics covered:

• Enhanced analysis of macromolecules and nanoparticles through DLS/SLS/ELS

• Analyzing proteins and RNA by SEC-MALS

• Advantages and benefits of SEC-MALS over conventional chromatography

• Characterization of protein conjugates using SEC-MALS

• Characterization of AAVs and lentiviruses by light scattering

• Capturing of LNP critical quality attributes by SEC/FFF-MALS.

• HRMS tools for protein biologics

• Q&A and individual consultations with Wyatt Technology scientists

Who should attend:

• Scientists who are interested in screening as well as in-depth characterization of proteins, protein conjugates, LNPs, AAVs, lentiviruses, and other viral vectors.
• People requiring sample quality assessment for process development and formulation studies.
• Anyone working on the development of therapeutic payload delivery systems.
• Researchers in the field of gene therapy.
• Active users of Wyatt light scattering instruments seeking to engage with regional colleagues around similar analytical challenges and wish to learn more about advanced topics related to Wyatt instruments and software.
• Anyone interested in learning more about light scattering and its manifold applications to proteins and biological nanoparticles.

For more information and registration, please contact Małgorzata Łopaciuk.