On-line Differential Refractometers for HPLC and UHPLC

Optilab

An on-line differential refractometer with extended range for universal concentration and dn/dc measurements.

The Optilab provides both exquisite sensitivity and 50 times the dynamic range of every other RI detector available. It is the only on-line detector offering temperature control both above and below ambient, as well as measurement of the absolute refractive index of solvents. A high concentration version measures protein concentration up to 180 mg/mL.

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microOptilab

Universal concentration measurement for use with all UHPLC systems.

The microOptilab is a unique Refractive Index detector that offers high sensitivity and 50 times the dynamic range of every other UHPLC RI detector. Like the Optilab, it offers temperature control both above and below ambient, as well as measurement of the absolute refractive index of solvents.

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Feature Comparison

Capabilities Optilab Optilab High Conc. microOptilab
Differential Refractive Index
Range -0.0047 to +0.0047 RIU -0.0026 to +0.034 RIU -0.0047 to +0.0047 RIU
Peak-to-Peak Noise ± 7.5 x 10-10 RIU ± 1.5 x 10-9 RIU ± 1.5 x 10-9 RIU
Dynamic Range 12,000,000:1 23,000,000:1 6,000,000:1
Acquisition Period 0.1 to 5 seconds/sample 0.1 to 5 seconds/sample 0.04 to 5 seconds/sample
Absolute Refractive Index
Range 1.2 to 1.8 RIU 1.2 to 1.8 RIU 1.2 to 1.8 RIU
Sensitivity ± 0.002 RIU ± 0.002 RIU ± 0.002 RIU
Fluidics
Band Broadening < 20 µL < 20 µL < 4 µL
Flow Cell & Inlet Tubing Volume 51.4 µL 51.4 µL 13.9 µL
Sample Temperature 4°C to 65°C 4°C to 65°C 4°C to 65°C