Dynamic Light Scattering Instruments

DynaPro Plate Reader

DynaPro Plate Reader III

High-throughput, automated dynamic light scattering.

The DynaPro Plate Reader III provides unparalleled levels of productivity and flexibility for the most demanding nanoparticle sizing and protein aggregation tasks such as biotherapeutic formulation, screening of promiscuous inhibitors, and optimization of protein crystallization conditions. Measurements are performed in situ with no fluid transfer. Select from industry-standard 96-, 384- or 1536-microwell plates.

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DynaPro NanoStar II

Traditional dynamic light scattering, just better.

The DynaPro NanoStar operates in traditional microcuvette-based format to analyze size distributions and particle concentrations of proteins, nanomedicines, viruses, vesicles, emulsions, micelles and metallic nanoparticles. It uniquely combines two optimized 90° detections channels: one for DLS and one for static light scattering. Providing walk-up operation via an intuitive touch-screen app, the NanoStar performs robust, accurate measurements with as little as 2 µL of sample.

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DynaPro ZetaStar

Walk-up or automated measurements of dynamic, static and electrophoretic light scattering.

The ZetaStar operates with an autosampler, or manually using microcuvettes, to measure a sample’s size distribution, particle concentration, molecular weight, turbidity, and zeta potential. Proteins, nanomedicines, viral vectors, extracellular vesicles, nano emulsions, and polymers can all be analyzed in a variety of solvents, including salt concentrations greater than physiological conditions.

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Feature Comparison

Capabilities DynaPro
Plate Reader
Nanoparticle Size Range (Rh, by DLS) 0.5 to 1000 nm 0.2 to 1000 nm 0.2 nm to 1 μm (cuvette)
0.2 nm to 400 nm (flow cell)
Molar Mass Range by SLS 1000 Da to 1 MDa 300 Da to 10 MDa* 300 Da to 10 MDa*
Sensitivity (lysozyme 14.4 kDa) 0.125 mg/mL 0.1 mg/mL 0.1 mg/mL
Electrophoretic Mobility Range N/A N/A No practical limit
Mobility Size Range N/A N/A 1 nm to 50 µm
Mobility Sensitivity N/A N/A 1 mg/mL Lysozyme
Minimum Sample Volume 4 µL (1536-well plate) 2 µL (quartz cuvette),
45 µL (quartz cuvette)
4 µL (disposable cuvette)
2 µL (quartz cuvette),
4 µL (disposable cuvette),
45 µL (quartz cuvette),
65 µL (dip cell)
400 µL (disposable flow cell)
350 µL (flow cell – batch)
500 µL (flow cell – pressurized/automation)
Laser Wavelength 830 nm 658 nm 785 nm
Laser Power Control Programmable 10% to 100% Programmable 10% to 100% Programmable 10% to 100%
Sample Cell Options 96-, 384- or 1536-well microwell plates. Industry standard disposable (choose from recommended list). SLS & DLS:
Quartz cuvettes
Generic glass cuvette

DLS only:
Disposable cuvette
Dip cell
Flow cell
Zeta disposable cell

Quartz cuvettee
Generic glass cuvette

DLS only:
Disposable cuvette
Generic disposable cuvette
Temperature Control 4 to 85 °C -10 to +120 °C -10 to +120 °C (DLS & SLS)
4 to 70 °C (ELS)

Upper limit depends on conformation: it is limited to a maximum Rh of 12 nm.

*Upper limit depends on conformation: it is limited to a maximum Rh of 50 nm.