Dynamic Light Scattering Instruments

DynaPro^® Plate Reader III

High-throughput, automated dynamic light scattering.

The DynaPro Plate Reader III provides unparalleled levels of productivity and flexibility for the most demanding nanoparticle sizing and protein aggregation tasks such as biotherapeutic formulation, screening of promiscuous inhibitors, and optimization of protein crystallization conditions. Measurements are performed in situ with no fluid transfer. Select from industry-standard 96-, 384- or 1536-microwell plates.

DynaPro^® NanoStar^® II

Traditional dynamic light scattering, just better.

The DynaPro NanoStar operates in traditional microcuvette-based format to analyze size distributions and particle concentrations of proteins, nanomedicines, viruses, vesicles, emulsions, micelles and metallic nanoparticles. It uniquely combines two optimized 90° detections channels: one for DLS and one for static light scattering. Providing walk-up operation via an intuitive touch-screen app, the NanoStar performs robust, accurate measurements with as little as 2 µL of sample.

Mobius^™

Automated electrophoretic mobility measurements of proteins and nanoparticles, in all types of solvents.

The Mobius connects to an autosampler to make reliable, reproducible, and non-destructive electrophoretic mobility measurements of macromolecules as small as 1 nm in radius, as well as micron-size nanoparticles. Versatile and sensitive, the Mobius characterizes the mobility of fragile biomolecules non-destructively, at low applied voltage, or nanometer-sized inorganic nanoparticles at high applied voltage.

Capabilities	DynaPro^® Plate Reader III	DynaPro^® NanoStar^® II	Mobius^™
Measurements
Nanoparticle Size Range (R_h, by DLS)	0.5 to 1000 nm	0.2 to 1000 nm	0.2 to 5000 nm (flow cell); 0.2 to 200 nm (dip cell, quartz cuvette); 0.2 to 250 nm (disposable cuvette)
Molar Mass Range by SLS	1000 Da to 1 MDa^†	300 Da to 10 MDa^*	N/A
Sensitivity (lysozyme 14.4 kDa)	0.125 mg/mL	0.1 mg/mL	0.1 mg/mL
Electrophoretic Mobility Range	N/A	N/A	no practical limit
Mobility Size Range	N/A	N/A	1 nm to 50 µm
Mobility Sensitivity	N/A	N/A	1 mg/mL lysozyme (flow cell); 5 mg/mL BSA (dip cell)
Fluidics
Minimum Sample Volume	4 µL (1536-well plate)	2 µL (quartz cuvette), 4 µL (disposable cuvette)	170 µL (flow cell); 45 µL (quartz cuvette)
Optics
Laser Wavelength	830 nm	658 nm	532 nm
Laser Power Control	Programmable 10% to 100%	Programmable 10% to 100%	Programmable 10% or 100%
Sample Cell Options	96-, 384- or 1536-well microwell plates. Industry standard disposable (choose from recommended list).	2 µL quartz cuvettes; 4 µL disposable cuvettes 4 mL generic glass cuvette	Mobility & DLS: 170 µL flow cell; 65 µL dip cell DLS only: 45 µL quartz cuvette; 100 µL disposable cuvette
Temperature Control	4 to 85 °C	-10 to +120 °C	4 to 70 °C

^†Upper limit depends on conformation: it is limited to a maximum R_h of 12 nm.

^*Upper limit depends on conformation: it is limited to a maximum R_h of 50 nm.

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DynaPro®Plate Reader III - Feature Comparison

Capabilities	DynaPro® Plate Reader III
Measurements
Nanoparticle Size Range (R_h, by DLS)	0.5 to 1000 nm
Molar Mass Range by SLS	1000 Da to 1 MDa
Sensitivity (lysozyme 14.4 kDa)	0.125 mg/mL
Electrophoretic Mobility Range	N/A
Mobility Size Range	N/A
Mobility Sensitivity	N/A
Fluidics
Minimum Sample Volume	4 µL (1536-well plate)
Optics
Laser Wavelength	830 nm
Laser Power Control	Programmable 10% to 100%
Sample Cell Options	96-, 384- or 1536-well microwell plates. Industry standard disposable (choose from recommended list).
Temperature Control	4 to 85°C

DynaPro® NanoStar - Feature Comparison

Capabilities	DynaPro® NanoStar® II
Measurements
Nanoparticle Size Range (R_h, by DLS)	0.2 to 1000 nm
Static Scattering Molecular Weight Range	300 Da to 1 MDa
Particle Concentration Range	1x10⁵ to 1x 10¹⁵ (dependent on size)
Sensitivity	0.1 mg/mL of 14.4 kDa lysozyme in PBS
Temperature Range	-10 °C to +120 °C* Maximum ramp rate 15 °C/min
Sample Options
Sample Cells	Quartz cuvette: 2 μL or 45 μL, Disposable cuvette (cyclic olefin copolymer), generic 4 mL quartz and disposable cuvettes (with adapter)
Minimum Sample Volume	2 μL in quartz cuvette; 4 μL in disposable cuvette
Optics
Laser Wavelength	658 nm
Laser Power Control	Programmable 10% to 100%
Scattering Angle	90°
Optical Fiber	Multi-mode
Additional Detectors	Laser monitor for active stabilization; Forward monitor measures transmitted light for turbidance and laser/cell diagnostics
Electronics
Data Acquisition Time	1 to 3600 sec
Correlator	512 channel, 100 nsec sampling time in a multi-tau layout
Dimensions	57 cm (L) x 36 cm (W) x 20 cm (H)
Weight	TBD

*Dry air or nitrogen required for operation below 20 °C.

Mobius™ - Feature Comparison

Capabilities	Mobius™
Measurements
Nanoparticle Size Range (R_h, by DLS)	0.2 to 5000 nm (flow cell); 0.2 to 200 nm (dip cell, quartz cuvette); 0.2 to 250 nm (disposable cuvette)
Molar Mass Range by SLS	N/A
Sensitivity (lysozyme 14.4 kDa)	0.1 mg/mL
Electrophoretic Mobility Range	no practical limit
Mobility Size Range	1 nm to 50 µm
Mobility Sensitivity	1 mg/mL lysozyme (flow cell); 5 mg/mL BSA (dip cell)
Fluidics
Minimum Sample Volume	170 µL (flow cell); 45 µL (quartz cuvette)
Optics
Laser Wavelength	532 nm
Laser Power Control	Programmable 10% or 100%
Sample Cell Options	Mobility & DLS: 170 µL flow cell; 65 µL dip cell DLS only: 45 µL quartz cuvette; 100 µL disposable cuvette
Temperature Control	4 to 70°C

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