Dynamic & Electrophoretic Light Scattering
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DynaPro Plate Reader III
High-throughput, automated dynamic light scattering.
The DynaPro Plate Reader III provides unparalleled levels of productivity and flexibility for the most demanding nanoparticle sizing and protein aggregation tasks such as biotherapeutic formulation, screening of promiscuous inhibitors, and optimization of protein crystallization conditions. Measurements are performed in situ with no fluid transfer. Select from industry-standard 96-, 384- or 1536-microwell plates.
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DynaPro NanoStar
Traditional dynamic light scattering, just better.
The DynaPro NanoStar operates in traditional microcuvette-based format to analyze sizes and size distributions of proteins, micelles, quantum dots, liposomes, and metallic nanoparticles. It uniquely combines two optimized 90° detections channels: one for DLS and one for static light scattering. Providing an extraordinary temperature range, the NanoStar performs robust, accurate measurements with as little as 1 µL of sample.
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Mobius
Automated electrophoretic mobility measurements of proteins and nanoparticles, in all types of solvents.
The Mobius connects to an autosampler to make reliable, reproducible, and non-destructive electrophoretic mobility measurements of macromolecules as small as 1 nm in radius, as well as micron-size nanoparticles. Versatile and sensitive, the Mobius characterizes the mobility of fragile biomolecules non-destructively, at low applied voltage, or nanometer-sized inorganic nanoparticles at high applied voltage.
Feature Comparison
| Capabilities |
DynaPro® Plate Reader III |
DynaPro® NanoStar |
Mobius® |
| Measurements | |||
| Nanoparticle Size Range (Rh, by DLS) | 0.5 to 1000 nm | 0.2 to 2500 nm | 0.2 to 5000 nm (flow cell); 0.2 to 200 nm (dip cell, quartz cuvette); 0.2 to 250 nm (disposable cuvette) |
| Molar Mass Range by SLS | 1000 Da to 1 MDa | 300 Da to 1 MDa | N/A |
| Sensitivity (lysozyme 14.4 kDa) | 0.125 mg/mL | 0.1 mg/mL | 0.1 mg/mL |
| Electrophoretic Mobility Range | N/A | N/A | no practical limit |
| Mobility Size Range | N/A | N/A | 1 nm to 50 µm |
| Mobility Sensitivity | N/A | N/A | 1 mg/mL lysozyme (flow cell); 5 mg/mL BSA (dip cell) |
| Fluidics | |||
| Minimum Sample Volume | 4 µL (1536-well plate) | 1.25 µL (quartz cuvette), 4 µL (disposable cuvette) |
170 µL (flow cell); 45 µL (quartz cuvette) |
| Optics | |||
| Laser Wavelength | 830 nm | 658 nm 785 nm optional |
532 nm |
| Laser Power Control | Programmable 10% to 100% | Programmable 10% to 100% | Programmable 10% or 100% |
| Sample Cell Options | 96-, 384- or 1536-well microwell plates. Industry standard disposable (choose from recommended list). | 1 µL and 45 µL quartz cuvettes; 4 µL disposable cuvettes |
Mobility & DLS: 170 µL flow cell; 65 µL dip cell DLS only: 45 µL quartz cuvette; 100 µL disposable cuvette |
| Temperature Control | 4 to 85°C | -15 to +150°C | 4 to 70°C |