Dynamic Light Scattering Instruments

DynaPro® Plate Reader III
High-throughput, automated dynamic light scattering.
The DynaPro Plate Reader III provides unparalleled levels of productivity and flexibility for the most demanding nanoparticle sizing and protein aggregation tasks such as biotherapeutic formulation, screening of promiscuous inhibitors, and optimization of protein crystallization conditions. Measurements are performed in situ with no fluid transfer. Select from industry-standard 96-, 384- or 1536-microwell plates.
DynaPro® NanoStar® II
Traditional dynamic light scattering, just better.
The DynaPro NanoStar operates in traditional microcuvette-based format to analyze size distributions and particle concentrations of proteins, nanomedicines, viruses, vesicles, emulsions, micelles and metallic nanoparticles. It uniquely combines two optimized 90° detections channels: one for DLS and one for static light scattering. Providing walk-up operation via an intuitive touch-screen app, the NanoStar performs robust, accurate measurements with as little as 2 µL of sample.


Mobius™
Automated electrophoretic mobility measurements of proteins and nanoparticles, in all types of solvents.
The Mobius connects to an autosampler to make reliable, reproducible, and non-destructive electrophoretic mobility measurements of macromolecules as small as 1 nm in radius, as well as micron-size nanoparticles. Versatile and sensitive, the Mobius characterizes the mobility of fragile biomolecules non-destructively, at low applied voltage, or nanometer-sized inorganic nanoparticles at high applied voltage.
Feature Comparison
Capabilities |
DynaPro® Plate Reader III |
DynaPro® NanoStar® II |
Mobius™ |
Measurements | |||
Nanoparticle Size Range (Rh, by DLS) | 0.5 to 1000 nm | 0.2 to 1000 nm | 0.2 to 5000 nm (flow cell); 0.2 to 200 nm (dip cell, quartz cuvette); 0.2 to 250 nm (disposable cuvette) |
Molar Mass Range by SLS | 1000 Da to 1 MDa† | 300 Da to 10 MDa* | N/A |
Sensitivity (lysozyme 14.4 kDa) | 0.125 mg/mL | 0.1 mg/mL | 0.1 mg/mL |
Electrophoretic Mobility Range | N/A | N/A | no practical limit |
Mobility Size Range | N/A | N/A | 1 nm to 50 µm |
Mobility Sensitivity | N/A | N/A | 1 mg/mL lysozyme (flow cell); 5 mg/mL BSA (dip cell) |
Fluidics | |||
Minimum Sample Volume | 4 µL (1536-well plate) | 2 µL (quartz cuvette), 4 µL (disposable cuvette) |
170 µL (flow cell); 45 µL (quartz cuvette) |
Optics | |||
Laser Wavelength | 830 nm | 658 nm | 532 nm |
Laser Power Control | Programmable 10% to 100% | Programmable 10% to 100% | Programmable 10% or 100% |
Sample Cell Options | 96-, 384- or 1536-well microwell plates. Industry standard disposable (choose from recommended list). | 2 µL quartz cuvettes; 4 µL disposable cuvettes 4 mL generic glass cuvette |
Mobility & DLS: 170 µL flow cell; 65 µL dip cell DLS only: 45 µL quartz cuvette; 100 µL disposable cuvette |
Temperature Control | 4 to 85 °C | -10 to +120 °C | 4 to 70 °C |
†Upper limit depends on conformation: it is limited to a maximum Rh of 12 nm.
*Upper limit depends on conformation: it is limited to a maximum Rh of 50 nm.
DynaPro®Plate Reader III - Feature Comparison
Capabilities | DynaPro® Plate Reader III |
Measurements | |
Nanoparticle Size Range (Rh, by DLS) | 0.5 to 1000 nm |
Molar Mass Range by SLS | 1000 Da to 1 MDa |
Sensitivity (lysozyme 14.4 kDa) | 0.125 mg/mL |
Electrophoretic Mobility Range | N/A |
Mobility Size Range | N/A |
Mobility Sensitivity | N/A |
Fluidics | |
Minimum Sample Volume | 4 µL (1536-well plate) |
Optics | |
Laser Wavelength | 830 nm |
Laser Power Control | Programmable 10% to 100% |
Sample Cell Options | 96-, 384- or 1536-well microwell plates. Industry standard disposable (choose from recommended list). |
Temperature Control | 4 to 85°C |
DynaPro® NanoStar - Feature Comparison
Capabilities | DynaPro® NanoStar® II |
Measurements | |
Nanoparticle Size Range (Rh, by DLS) | 0.2 to 1000 nm |
Static Scattering Molecular Weight Range | 300 Da to 1 MDa |
Particle Concentration Range | 1x105 to 1x 1015 (dependent on size) |
Sensitivity | 0.1 mg/mL of 14.4 kDa lysozyme in PBS |
Temperature Range | -10 °C to +120 °C* Maximum ramp rate 15 °C/min |
Sample Options | |
Sample Cells | Quartz cuvette: 2 μL or 45 μL, Disposable cuvette (cyclic olefin copolymer), generic 4 mL quartz and disposable cuvettes (with adapter) |
Minimum Sample Volume | 2 μL in quartz cuvette; 4 μL in disposable cuvette |
Optics | |
Laser Wavelength | 658 nm |
Laser Power Control | Programmable 10% to 100% |
Scattering Angle | 90° |
Optical Fiber | Multi-mode |
Additional Detectors | Laser monitor for active stabilization; Forward monitor measures transmitted light for turbidance and laser/cell diagnostics |
Electronics | |
Data Acquisition Time | 1 to 3600 sec |
Correlator | 512 channel, 100 nsec sampling time in a multi-tau layout |
Dimensions | 57 cm (L) x 36 cm (W) x 20 cm (H) |
Weight | TBD |
*Dry air or nitrogen required for operation below 20 °C.
Mobius™ - Feature Comparison
Capabilities | Mobius™ |
Measurements | |
Nanoparticle Size Range (Rh, by DLS) | 0.2 to 5000 nm (flow cell); 0.2 to 200 nm (dip cell, quartz cuvette); 0.2 to 250 nm (disposable cuvette) |
Molar Mass Range by SLS | N/A |
Sensitivity (lysozyme 14.4 kDa) | 0.1 mg/mL |
Electrophoretic Mobility Range | no practical limit |
Mobility Size Range | 1 nm to 50 µm |
Mobility Sensitivity | 1 mg/mL lysozyme (flow cell); 5 mg/mL BSA (dip cell) |
Fluidics | |
Minimum Sample Volume | 170 µL (flow cell); 45 µL (quartz cuvette) |
Optics | |
Laser Wavelength | 532 nm |
Laser Power Control | Programmable 10% or 100% |
Sample Cell Options | Mobility & DLS: 170 µL flow cell; 65 µL dip cell DLS only: 45 µL quartz cuvette; 100 µL disposable cuvette |
Temperature Control | 4 to 70°C |