Wyatt Technology

Upcoming Live Webinars

Predicting and evaluating the stability of therapeutic protein formulations by dynamic light scattering and machine learning

Join us for a webinar on October 23 at 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST

PIPPI, which stands for Protein-excipient Interactions and Protein-Protein Interactions, is a European academic-industrial consortium addressing the challenges in formulation of protein-based drugs. Its overall objective is to develop methodologies, tools and databases to guide the rational formulation of robust protein-based therapeutics. Much of the effort carried out under PIPPI has utilized dynamic light scattering (DLS), the primary biophysical technique for screening aggregation in a high-throughput fashion.

Thanks to efficient utilization of resources and high flexibility, DLS can be applied in multiple ways to increase the progression of new-drug candidates into phase 1 clinical trial. In this webinar a series of DLS methods are presented for evaluating stability under different formulations, including standard protocols and the latest applications. All, if not most, of these methods are carried out in high-throughput fashion using convenient microwell plates in order to test a large variety of candidates and formulation conditions.

Due to the overwhelming amount of data available from high throughput techiniques such as plate-based DLS, there is a staggering increase in opportunities for finding patterns in data. Such a patterns are helpful in ab initio prediction of stability-indicating parameters. A machine learning application developed to identify those patterns, and trained using a standard formulation screening dataset, is shown.

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The Importance of Light Scattering in Biopharmaceutical Formulation Development

Join us for a webinar on November 15 at 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST

Protein formulation development and characterization relies heavily on a set of analytical tools and techniques to accurately assess a molecule’s stability. This toolbox includes a standard set of tools which has come to us through industry wisdom and experience.

Light scattering is increasingly considered a “standard” tool in the set, and it is a core part of Fujifilm’s approach to protein formulation development. We will introduce how various types of light scattering measurements are used in our work and offer several case studies where light scattering data impacted the project direction or was the only way to accurately measure the product.

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Recent Webinars

Previous webinars may be viewed in our Webinar Library. The following recent webinars are now available:

 

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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.



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