Upcoming Live Webinars

Separation and Characterization of Complex (Bio)macromolecular Architectures

Join us for a webinar on April 24 at 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST

Soft materials such as highly-branched, responsive or dynamic polymers have great potential for advanced applications. The basis for this potential is the versatility, tunability and high functionality of the polymer systems and of their well-defined nanoscale structures. Understanding these materials and how to adjust their scaling parameters on a molecular level is crucial for controlled design to meet application requirements.
In this webinar, I compare techniques for characterizing the properties and interactions of highly-functionalized polymers, highly-branched polymers, biohybrids and similar complex systems. These techniques include field-flow fractionation coupled to multiple types of detectors, and complementary methods such as AFM, cryo-TEM and MD simulations. I also discuss the relation between conformation and interactions, which is highly relevant for biological applications.

Crystallized Biotherapeutics: Optimizing mAb Crystallization using Light Scattering

Join us for a webinar on May 15 at 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST

The Crystalomics® Department at Ajinomoto Althea CMO uses crystallized biotherapeutics to develop high concentration, low viscosity injectable drug formulations exceeding 200 mg/mL. The first step in our technology is to discover and develop crystallization conditions as rapidly as possible in order to meet short development timelines.

Crystallization of proteins, especially monoclonal antibodies (mAbs), is very challenging and typically employs extensive trial-and-error. Incorporating high-throughput dynamic light scattering (HT-DLS) into our pre-crystallization screening to characterize the protein in multiple buffers, we are able to significantly reduce the extent of crystallization trials. Analysis of the mAbs by multi-angle light scattering coupled to size-exclusion chromatography (SEC-MALS) as well as HT-DLS is critical to determining optimal crystallization conditions with minimal time and effort.

Recent Webinars

Previous webinars may be viewed in our Webinar Library. The following recent webinars are now available:

• Understanding monoclonal antibody unfolding and aggregation
• Applications of Light Scattering to HIV Integrase Structural Biology and Drug Discovery
• µSEC-MALS adds Multi-Angle Light Scattering to UHP-SEC for Measurement of Absolute Molecular Weight and Size
• Applications of Analytical Light Scattering in a Biophysics Core Facility
• Quickly Screen Peptides, Proteins and Nanoparticles for Size and Aggregation Using Advanced Methods
• Advances in High-Throughput Screening of Aggregation, Stability and Viscosity Utilizing Light Scattering in Microwell Plates
• Absolute Characterization of Polymeric Excipients with Size Exclusion Chromatography and Light Scattering
• Absolute Characterization of Glycoproteins and their Interactions with Proteins and Antibodies by Light Scattering
• Essential Polymer Characterization with MALS and FFF
• Small, but bright: µSEC-MALS adds light scattering to UHP-SEC for biophysical characterization of biotherapeutics
• Characterizing Molecular Structure in Synthetic and Natural Polymers by Multi-Angle Light Scattering
• Innovations and Applications of UHP-SEC and Multi-Angle Light Scattering (MALS) for the Analysis of Biotherapeutic Proteins
• Advances in online viscometry: extending the limits of detection for intrinsic viscosity and hydrodynamic radius

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