Wyatt Technology

Upcoming Live Webinars

Separation and Characterization of Complex (Bio)macromolecular Architectures

Join us for a webinar on April 24 at 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST

Soft materials such as highly-branched, responsive or dynamic polymers have great potential for advanced applications. The basis for this potential is the versatility, tunability and high functionality of the polymer systems and of their well-defined nanoscale structures. Understanding these materials and how to adjust their scaling parameters on a molecular level is crucial for controlled design to meet application requirements.
In this webinar, I compare techniques for characterizing the properties and interactions of highly-functionalized polymers, highly-branched polymers, biohybrids and similar complex systems. These techniques include field-flow fractionation coupled to multiple types of detectors, and complementary methods such as AFM, cryo-TEM and MD simulations. I also discuss the relation between conformation and interactions, which is highly relevant for biological applications.

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Crystallized Biotherapeutics: Optimizing mAb Crystallization using Light Scattering

Join us for a webinar on May 15 at 8:00 AM PDT | 11:00 AM EDT | 17:00 CEST

The Crystalomics® Department at Ajinomoto Althea CMO uses crystallized biotherapeutics to develop high concentration, low viscosity injectable drug formulations exceeding 200 mg/mL. The first step in our technology is to discover and develop crystallization conditions as rapidly as possible in order to meet short development timelines.

Crystallization of proteins, especially monoclonal antibodies (mAbs), is very challenging and typically employs extensive trial-and-error. Incorporating high-throughput dynamic light scattering (HT-DLS) into our pre-crystallization screening to characterize the protein in multiple buffers, we are able to significantly reduce the extent of crystallization trials. Analysis of the mAbs by multi-angle light scattering coupled to size-exclusion chromatography (SEC-MALS) as well as HT-DLS is critical to determining optimal crystallization conditions with minimal time and effort.

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Recent Webinars

Previous webinars may be viewed in our Webinar Library. The following recent webinars are now available:

 

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Ultimate Guide

Thirteen key questions to ask when buying a Multi-Angle Light Scattering (MALS) or Dynamic Light Scattering (DLS) instrument.

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Our Solutions Catalog combines Wyatt's product lines, applications and services into a single comprehensive booklet.

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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.



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