Upcoming Live Webinars
Breakthroughs in FFF-MALS – new levels of performance and usability
Join us for a webinar on October 27, 8:00 AM PDT | 11:00 AM EDT | 17:00 CET
Field-flow fractionation coupled to light scattering (FFF-MALS) is a powerful method for characterizing nanoparticles, proteins and polymers. For nanoparticles with sizes from 1 to 1000 nm, FFF-MALS uniquely provides high-resolution size distributions, quantitative particle concentration and other types of on-line characterization, along with the ability to collect size fractions. For macromolecules ranging from a few kDa to 1 GDa, FFF-MALS determines absolute molar mass, size and conformation while overcoming the inherent limitations of SEC for larger polymers and aggregates.
In this webcast, the next generation in FFF-MALS will be introduced. Technological advancements greatly enhance sensitivity, fraction concentrations, and the ability to measure zeta potential distributions via EAF4. The new capabilities also improve experimental robustness and ease of use. The simplified workflow, from in silico method development to final analysis, will be presented.
Rational use of dynamic light scattering for the characterization of cytokines, bispecific antibody fusion proteins and binary antibody mixtures
Join us for a webinar on November 17, 2020 at 8am PST| 11am EST| 5pm CET
The rational biophysical characterization of therapeutic protein candidates and their formulations can greatly improve the early-stage development process of new biologics. As a part of this characterization, dynamic light scattering (DLS) is a valuable technique that can be applied to understand the aggregation behavior and colloidal stability of proteins in solution.
This webinar will present three case studies in which DLS was crucial to understanding the stability of therapeutically relevant proteins. The first study shows how DLS in multi-well plates can quickly indicate which solution conditions are expected to suppress the aggregation of a cytokine during long-term storage. The second part of the presentation will focus on the characterization of a bispecific antibody fusion protein in different formulations, and how DLS-based formulation ranking correlates with the ranking based on aggregates formed after long-term storage. The third case study examines binary mixtures of monoclonal antibodies with different biophysical properties and how DLS helps investigate whether the antibodies mutually impair their physical stability in solution.
Previous webinars may be viewed in our Webinar Library. The following recent webinars are now available:
Daniel Some, Ph.D., Wyatt Technology
September 22, 2020
French webinar: Real-Time MALS: A Breakthrough in Process Analytical Technology for Nanoparticles, Biopharmaceuticals and Polymers
Thierry Azoulay, Wyatt Technology
September 22, 2020
Lionel Rouzic, Ingénieur Applications
Predicting stability of antibody therapeutics by unfolded-state studies with high-throughput dynamic light scattering (HT-DLS)
Robin Curtis, Ph.D., University of Manchester
August 18, 2020
Nemal Gobalasingham, Ph.D., Wyatt Technology
July 21, 2020
Carlos Kikuti, Ph.D., Institut Curie
Felix Gloge, Ph.D., Wyatt Technology
June 23, 2020
June 18, 2020
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