Empower™
Software Solutions for MALSEmpower™ Software Solutions, our flagship suite of chromatographic data system (CDS) and laboratory management (LMS) solutions for liquid chromatography (LC) supports select collection, processing and reporting of results from DAWN™ multi-angle light scattering (MALS), and Optilab™ differential refractive index (RI) instruments line.
This functionality makes it easier than ever to run samples and produce meaningful results for proteins, peptides, and other biomolecules in a regulatory-compliant system that is highly scalable and integrates into various business processes, ensuring optimized, traceable, and robust data flow.
We offer industry-leading MALS data acquisition and processing no matter which stage of development you may be in - from discovery with cutting-edge multi-detector analysis to robust, efficient, and routine analysis in regulated QC environments.
Choose ASTRA™ software for broad characterization capabilities and pioneering workflows customized for specific modalities (i.e., AAV, LNP, polymer branching).
Select Empower CDS for enterprise-wide integration and robust automation features for analysis and reporting as the method transfers to QC for best-in-class compliance and traceability.
The table below compares functionality, support, and characterization capabilities in Empower CDS compared to ASTRA software so that you can make an informed decision and benefit from the strengths of either solution.
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| Enterprise Capable | ||
| Integrated with LIMS/ELNs | ||
| Simplified Validation | ||
| Regulatory Compliance | ||
| Broad Waters LC Support (HPLC CONNECT 4 supports Waters LC modules listed here.) | ||
| Integrated Workflows & Flexible Analysis | ||
| MALS-based analysis of specific physical properties of proteins and polymers | ||
| Modality-Specific Analyses (e.g., LNP, AAV, Polymer Branching) | ||
| Specialized Wyatt Instrument Support (e.g., Viscometry, FFF) |
Empower CDS with built-in MALS acquisition and analysis streamlines workflows in regulated environments. The integrated system supports electronic records and enables unified reporting with complementary and orthogonal techniques, including mass spectrometry, all maintained within a best-in-class compliance-ready environment.
Scientists in Discovery, R&D, and Analytical Development can develop methods, validate quality attributes, and determine product specifications using the full functionality of ASTRA software, before transferring the method to Quality Control and other regulated environments for use with Empower Software.
Included MALS Analysis within Empower Software
Molar Mass Determination
Molar Mass via Light ScatteringLight scattering stands alone in its ability to measure the molar mass of macromolecules in solution both accurately and quickly.
Distributions
Molar mass is determined across peaks in a chromatography run, and moments such as number- weight- and z-average are calculated. Empower Software also supports visualizing the distribution of these measured quantities.
Band Broadening Correction
Empower Software employs robust band-broadening correction to account for interdetector dispersion effects, giving you the most accurate results possible.
Peak Statistics
Analyze the performance of your column and chromatography system with the built-in reports for column plate count, peak width and asymmetry factor in Empower Software.
Empower Software streamlines chromatographic workflows, enhancing compliance, quality, and productivity for analysts, administrators, and IT teams. It's scalable information management meets lab-to-enterprise needs, while built-in method development, validation tools, and data migration capabilities ensure long-term data integrity.
Data analysis and information-sharing features include:
- Save Time: Reduce manual integration and achieve more precise peak calculations with built-in algorithms, all while enabling efficient batch analysis.
- Custom Calculations: Set custom parameters and calculations within Empower Software, eliminating the risk of errors from manual calculation.
- Anomaly Detection: Compare chromatograms to an optimal benchmark to quickly identifying satisfactory results and reducing manual analysis time.
- Seamless Sharing: Store, access, and share results across labs and projects, with easy report generation and remote collaboration.
- Fast Retrieval: Linked databases allow quick searches, automatic time stamps, and simplified audit preparation.
Empower CDS is a well-developed, validation-ready software with over 30 years of networked data, more than 500,000 software licenses sold, and over 5,000 network installations. Built-in compliance tools, including data security, change control, and traceability, enable adherence to regulatory requirements such as GxP, 21 CFR Part 11, Annex 11, and ISO 17025.
- 21 CFR Part 11 compliance-ready
- Data Integrity: Ensures the accuracy and consistency of data over its entire lifecycle.
- System Documentation: Comprehensive documentation for system configuration and operation with electronic signatures.
- Backup and Recovery: Implement procedures to prevent data loss.
- Access Controls: Manage user permissions to ensure only authorized personnel can access specific data and functions with flexibility on assignments.
- Change Control and Audit Trails: Track and manages changes to the system to ensure they are authorized and documented.
- Training Records: Maintain records of user training to ensure all personnel are adequately trained on the system.
Validated HPLC-MALS Systems
- DAWN™ (NEON™) MALS detector,
- miniDAWN™ (NEON) MALS detector,
- Optilab™ (NEON) dRI detector
Software System Requirements
Please refer to the support section of the Empower CDS pages for certificates, specifications, release notes and user manuals.