Characterization of hyaluronic acid with on-line differential viscometry, multi-angle light scattering, and differential refractometry

Wyatt Technology, in collaboration with Professor Skip Rochefort's group at Oregon State University, used a DAWN EOS, an Optilab rEX and a ViscoStar to measure the intrinsic viscosity and Mark-Houwink-Sakurada (MHS) behavior of Hyaluronic Acid (HA). Unusual MHS behavior was demonstrated, perhaps helping explain the large variation in HA MHS coefficients that have been reported in the literature.

Waters, J.; Leiske, D. LCGC  2005, 23, 302-310.   Link to Article