Biotherapeutics Application Notes

Aggregation, conjugation, formulation, and interaction in drug development.

Overview
SEC-MALS
SEC-MALS-DLS
SEC-MALS-IV
IEX/RPC-MALS
UHPLC-SEC-MALS
FFF-MALS
FFF-MALS-DLS
CG-MALS
DLS
ELS
Batch MALS
RT-MALS

Biotherapeutics Application Notes

White Papers

WP9007: Characterizing Vaccines with Light Scattering

Aggregate Analyses by Light Scattering – Complementary and Orthogonal [poster]

E-book: Solutions for Lipid Nanoparticle Characterization in Product and Process Development

PL9008: Key publications on the characterization of gene vectors by light scattering

PL9006: Key publications on the characterization of vaccines with multi-angle and dynamic light scattering

E-Book: Biopharmaceutical characterization: Improve predictive screening

E-Book: Characterizing Vaccines with the Light Scattering Toolkit

Application Notes

PH1001: The Role of Multi-Angle Light Scattering in Biosimilar Characterization and Approval

AN2004: Why and how to quantify AAV aggregates by FFF-MALS

AAV Application Notebook

White Papers

WP1621: Multi-Attribute Quantitation of Antibody-Drug Conjugates (ADCs) by LC MALS

WP1618: Enhanced SEC-MALS analysis of therapeutic mAbs, biosimilars and AAVs with XBridge Premier columns

E-book: Optimizing the analysis of viral vectors with light scattering

WP1615: SEC-MALS for absolute biophysical characterization

E-book: Advancing biopharma analysis with light scattering

Application Notes

AN1901: Identification of GLP-1 analog oligomeric states using SEC-MALS

AN1617: AAV critical quality attribute analysis by SEC-MALS

Next Steps in AAV Characterization via Light Scattering Measuring AAV Critical Quality Attributes [poster]

AN3002: Understanding Antibody and Viral Glycoprotein Interactions

AN6301: Discriminating Heparin from Chondroitin Sulfate by Charge: Mass Ratio

Vaccines: Forced Aggregation of Antigens [poster]

Polysaccharides: Low Molecular Weight Heparins Used as Anticoagulants

AN1616: SEC-MALS method for characterizing mRNA

AN1612: Protein PEGylation Processes Characterized by SEC-MALS

AN1609: Drug-Antibody Ratio Analysis in ADCs

AN1606: Assessing Ligand-Binding Assay Reagent Proteins

AN1605: Identification of Insulin Oligomeric States

AN1306: QC Validation of a Polyvalent Polysaccharide Pneumococcal Vaccine

Aggregation of a Recombinant Protein: Comparison of SEC-MALS, SEC-QELS and Plate-Based DLS [poster]

Application Notes

Aggregation of a Recombinant Protein: Comparison of SEC-MALS, SEC-QELS and Plate-Based DLS [poster]

Application Notes

White Papers

WP1621: Multi-Attribute Quantitation of Antibody-Drug Conjugates (ADCs) by LC MALS

WP8003: IEX-MALS for protein separation and characterization

Application Notes

Application Notes

AN1611: High Speed Process Monitoring with UHP-SEC-MALS

White Papers

WP2612: Meeting regulatory needs in the characterization of lipid nanoparticles (LNPs) for RNA delivery via FFF-MALS

WP2606: Exosome-characterization-by-FFF-MALS-DLS

WP9003: VLP Characterization with the Light Scattering Toolbox

PL2609: FFF-MALS-DLS nanoDDS key publications

Application Notes

AN2615: Multi-attribute quantification of LNP-mRNA therapeutics by FFF-MALS and DLS

AN2614: Virus-like particle characterization using FFF-MALS

Vaccines: Virus Particle Characterization

AN9010: Characterizing lentiviral and gammaretroviral vectors by batch DLS and FFF-MALS

Next Steps in AAV Characterization via Light Scattering Measuring AAV Critical Quality Attributes [poster]

Vaccines: VLPs Packed with DNA Payload [poster]

Vaccines: Recombinant Adenovirus

Vaccines: Protein-Polysaccharide Conjugates [poster]

Vaccines: Characterization of Virus-Like Particles by Asymmetrical Flow Field-Flow Fractionation

Silver Nanolipids [poster]

Separation of GCSF using AF4

Polysaccharides: Separation of Hyaluronic Acid on Frit-Inlet FFF-MALS [poster]

Peptide Hormone Aggregation

Monoclonal Antibodies and the Preparative Use of Asymmetric Flow Field-Flow Fractionation (AF4)

IgG Aggregation via Fluorescent Dye Detection

Hydroxyethylstarches (HES)

Endotoxin-Free Separation of Protein Species

Dendrimers [poster]

Botulism Antitoxin Characterization

AN2602: Size Distributions of Liposomes and Virus Particles by FFF-MALS

Aggregation of Antibody-Drug Conjugates [poster]

White Papers

WP2606: Exosome-characterization-by-FFF-MALS-DLS

PL2609: FFF-MALS-DLS nanoDDS key publications

Application Notes

AN9010: Characterizing lentiviral and gammaretroviral vectors by batch DLS and FFF-MALS

White Papers

WP9003: VLP Characterization with the Light Scattering Toolbox

PL3011: CG-MALS key publications on hetero-association

PL3010: CG-MALS key publications on self-association

PL3012: Patent applications using CG-MALS