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CG-MALS Application Notes

Biomolecular interactions using the Calypso^® composition-gradient system.

Search Notes

Biotherapeutics
Proteins

White Papers

WP9007: Characterizing Vaccines with Light Scattering
Aggregate Analyses by Light Scattering – Complementary and Orthogonal [poster]
PL3011: CG-MALS key publications on hetero-association
PL3012: Patent applications using CG-MALS
PL3010: CG-MALS key publications on self-association
WP9003: VLP Characterization with the Light Scattering Toolbox
E-book: Advancing biopharma analysis with light scattering

Application Notes

AN3009: Self-Associating Antibody Solutions at High Concentrations
AN3007: Estimating protein partitioning in multicomponent aqueous two-phase extraction based on CG-MALS measurements
AN3002: Understanding Antibody and Viral Glycoprotein Interactions
AN3003: Lot-to-Lot Comparability Studies of Monoclonal Antibodies
AN3004: Self-Association of Insulin: Affinity and Stoichiometry
PEG-Protein Interactions for Stable Formulations [poster]
Kinetics of Covalent Thrombin-Antithrombin Association
Competitive Binding Between Thrombin, Antithrombin III, and a Monoclonal Anti-Thrombin Antibody
Binding of Thrombin-α and an Anti-Thrombin Antibody

White Papers

Aggregate Analyses by Light Scattering – Complementary and Orthogonal [poster]
PL3011: CG-MALS key publications on hetero-association
PL3010: CG-MALS key publications on self-association
WP9003: VLP Characterization with the Light Scattering Toolbox
WP3001: Characterizing protein-DNA interactions
Protein-Protein-Small Molecule Interactions – Inhibition Kinetics and Dissociation
Characterizing Protein-Protein Interactions via Static Light Scattering: Reversible Hetero-association
Characterizing Protein-Protein Interactions via Static Light Scattering: Nonspecific Interactions

Application Notes

AN3009: Self-Associating Antibody Solutions at High Concentrations
AN3008: Metacomplex Formation & Affinity of Multivalent Binding Partners
AN3002: Understanding Antibody and Viral Glycoprotein Interactions
AN3005: Evaluation binding of individual and combined domains in the bacterial flagellar motor complex by CG-MALS
AN3006: Fusion-protein complexes analyzed by CG-MALS
Standard Zimm Plot
Self-Association of an Ion Transport Protein [poster]
Multivalent Protein-Aptamer Interaction
Multi-Domain Interactions in the Bacterial Flagellar Motor Complex
Conjugate Analysis: Lipid Transport Proteins [poster]
Characterization of Heparin Binding to Tau Protein via CG-MALS

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Ultimate Guide

Thirteen key questions to ask when buying a Multi-Angle Light Scattering (MALS) or Dynamic Light Scattering (DLS) instrument.

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Solutions Guide

Our Solutions Guide combines Wyatt's product lines, applications and services into a single comprehensive booklet.

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Biologics Guide

Our Biologics Guide highlights tools and techniques for characterizing biologics and complex drugs.

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Light Scattering University

Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS) and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry and differential viscosity.

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