Accelerating Downstream Process Development for Biologics, Gene Vectors and Vaccines
Presented by: Dan Some, Ph.D., Waters | Wyatt Technology
Presented Live: May 21, 2025
Downstream process development usually requires numerous iterations until optimization is achieved. Offline analytics are often a bottleneck for timely development. The antidote to lagging offline analytics is inline or online process analytical technology (PAT).
Real-time multi-angle light scattering (RT-MALS) is a PAT that monitors fundamental biophysical product attributes like molar mass, size and titer, every second during downstream operations such as FPLC or UF/DF. For AAVs, RT-MALS also monitors the full capsid ratio. This webinar describes the technology of RT-MALS and its implementation with a variety of bioprocess unit operations and modalities, from proteins to viral vectors, LNPs and pneumococcal vaccines.