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Site Map
Application Notes
- WP1618: Enhanced SEC-MALS analysis of therapeutic mAbs, biosimilars and AAVs with XBridge Premier columns
- eBook: Light-scattering Techniques to Characterize Therapeutic Gene Vectors
- AN6002: Automated Measurements of Electrophoretic Mobility
- AN2004: Why and how to quantify AAV aggregates by FFF-MALS
- Freeze-Thaw Stability Using Light Scattering
- E-book: Optimizing the Analysis of Viral Vectors with Light Scattering
- E-Book: Biopharmaceutical characterization: Improve predictive screening
- AN9010: Characterizing lentiviral and gammaretroviral vectors by batch DLS and FFF-MALS
- E-book: Solutions for Lipid Nanoparticle Characterization in Product and Process Development
- WP2612: Meeting regulatory needs in the characterization of lipid nanoparticles (LNPs) for RNA delivery via FFF-MALS
- AN4003: Influence of heating rates on the thermostability characterization of antibodies by DLS and SLS
- AN3010: Analysis of hetero-oligomers with CG-MALS
- AAV Application Notebook
- WP2900: Innovations in FFF – Eclipse (NEON)
- E-Book: Beyond GPC: Using Light Scattering for Absolute Polymer Characterization
- E-Book: Biopharmaceutical characterization: Improve predictive screening
- RT-MALS: Real-Time Process Analytics and Control for Vaccine Nanoparticles and Macromolecules [poster]
- PL5011: Key publications on high-throughput screening of therapeutic protein formulations by light scattering
- PL9008: Key publications on the characterization of gene vectors by light scattering
- AN7003: Conformational properties of hyperbranched hetero-polysaccharides by SEC-MALS-IV
- AN3007: Estimating protein partitioning in multicomponent aqueous two-phase extraction based on CG-MALS measurements
- E-book: Characterizing Vaccines with the Light Scattering Toolkit
- WP2304: Analysis of polymers in organic solvents by FFF-MALS
- E-book: Optimizing the Analysis of Viral Vectors with Light Scattering
- WP9007: Characterizing Vaccines with Light-Scattering
- WP5003: DynaPro Plate Reader III Automated dynamic and static light scattering in microwell plates for fast, productive development of biologics
- PL9006: Key publications on the characterization of vaccines with multi-angle and dynamic light scattering
- Next Steps in AAV Characterization via Light Scattering Measuring AAV Critical Quality Attributes [poster]
- AN8005: RT-MALS end-point determination of a polysaccharide depolymerization process
- AN8006: In-line monitoring of liposome size by RT-MALS
- PL3010: CG-MALS key publications on self-association
- PL3012: Patent applications using CG-MALS
- PL3011: Key publications on the characterization of protein hetero-association by CG-MALS
- PL0309: FFF-MALS-ICP-MS Key Publications
- AN5007: AAV quantitation and stability analysis by batch DLS
- AN1617: AAV critical quality attribute analysis by SEC-MALS
- E-book: Advancing HPLC/ UHPLC Analysis with Multi-Angle Light Scattering Technology
- PL2610: FFF-MALS-ICP-MS key publications
- WP2303: SEC-MALS and FFF-MALS characterization of lignin and lignosulfonates
- WP9002: Characterization of Fluorescent Macromolecules and Nanoparticles
- AN3002: Understanding Antibody and Viral Glycoprotein Interactions
- Au Nanoparticles in a Complex Biological Matrix
- WP9003: VLP Characterization with the Light Scattering Toolbox
- WP7002: ViscoStar – Innovations in Online Viscometry
- WP5010: High-Throughput DLS for Biotherapeutics Development
- High Throughput Dynamic Light Scattering for Screening Biotherapeutic Formulations
- Very Low Molar Mass Determination
- Characterizing Stable Protein Formulations
- Monitoring Protein Complex Formation in Solution
- Polymersomes (Vesicles)
- Protein Folding
- Dental Enamels
- Characterization of α-synuclein Oligomerization
- Liposome Characterization by Dynamic Light Scattering
- Glycolytic Enzyme Enolase
- AN4004: Conformation of a Trimeric Protein by DLS
- Measurement of Mixed Micelle Size
- WP4005: Determination of critical micelle concentration by dynamic light scattering
- Non-Specific Small Molecule Aggregation
- Elastin-Like Polypeptides (ELP) Block Co-Polymers
- Verification of Protein Aggregate Removal
- Screening High-Concentration Protein-Protein Interactions
- AN2614: Virus-like particle characterization using FFF-MALS
- Separation of GCSF using AF4
- Lipid Emulsions
- Vaccines: Virus Particle Characterization
- Peptide Hormone Aggregation
- Particle Characterization
- Thermal Field-Flow Fractionation of Aramides
- Vaccines: Characterization of Virus-Like Particles by Asymmetrical Flow Field-Flow Fractionation
- AN2005: Characterizing size distributions of broadly heterogeneous proteins with FFF-MALS
- IgG Aggregation via Fluorescent Dye Detection
- Endotoxin-Free Separation of Protein Species
- Characterizing Protein-Protein Interactions via Static Light Scattering: Nonspecific Interactions
- Characterizing Protein-Protein Interactions via Static Light Scattering: Reversible Hetero-association
- AN3008: Metacomplex Formation & Affinity of Multivalent Binding Partners
- Mega-Dalton Protein Complexes
- Quality Control of Epoxy Resins
- Polyacrylamides
- Silicones
- High Temperature GPC of Polyethylenes & Polypropylenes
- Synthetic Rubber
- Long-Term Reproducibility of SEC-MALS – a Five-Year Study
- Polyethylene Oxide Conformation
- Time-Dependent Light Scattering Studies
- Glutenin Protein Polymers
- Degradation of High Molar Mass Polymers
- Telechelic Associative Polymers
- Polyvinylcarbazole
- Automated Electrophoretic Mobility Measurement of High Salt Solutions
- Computation of Protein Net Charge from Electrophoretic Mobility
- Membrane Protein Quaternary Structure Analysis and Detergent Selection
- DARPins Complex Characterization
- Response Regulator Activation
- Determination of the Stoichiometry of Protein-Protein Complexes
- PEGylated Proteins
- Hemoglobin – Unusual SEC Elution Properties
- Protein-Protein Interactions: Scaling-up a Purification Protocol
- Overcoming Protein Fluorescence in MALS Measurements
- On-Line MALS-DLS Characterization of Proteins with Unusual Elution Properties
- Heat Shock Proteins – Temperature Dependence
- Calsequestrin, a Calcium Storage Protein
- Ribosomal Subunits in Protein Biosynthesis
- Automated, Low-Volume Second Virial Coefficient Measurement
- Stoichiometry of Lysin Holoenzyme
- Gluten Proteins
- Spongiform Encephalopathies
- Role Of Oligomeric Size in the Chaperone Function of αB-Crystallin
- Automated Second Virial Coefficient Determination Using a Binary HPLC Pump
- AN9009: Determination of dn/dc with an Optilab
- Characterization of Hyaluronic Acid
- Polysaccharides: Agarose Characterized at Elevated Temperatures
- Cosmetics: Aloe Extracts
- Acidified Proteins + Amylopectin
- Critical Micelle Concentration
- DNA Characterization
- Self-aggregation of Gelatin
- Polysaccharides: Polysulphide Pulping on Softwood Polysaccharides
- Electron Beam Irradiation & Cellulose Depolymerization
- Polysaccharides: Unfractionated Heparin
- Hydroxyethylstarches (HES)
- Stabilization of a Protein by a Peptide Mini-Chaperone [poster]
- Monitoring RNA Folding Intermediates [poster]
- Aggregation of Combinatorial Tau Protein [poster]
- PEG-Protein Interactions for Stable Formulations [poster]
- Dendrimers [poster]
- Vaccines: Protein-Polysaccharide Conjugates [poster]
- Polysaccharides: Separation of Hyaluronic Acid on Frit-Inlet FFF-MALS [poster]
- Stability of Enzyme Quaternary Structure [poster]
- Aggregate Analyses by Light Scattering – Complementary and Orthogonal [poster]
- Cellulose Ethers [poster]
- Polysaccharides: Sugar Beet Pectin [poster]
- Vaccines: VLPs Packed with DNA Payload [poster]
- Synthetic Polymer Characterization by AF4-MALS [poster]
- WP2608: Lipid Nanoparticle and Liposome Characterization with FFF-MALS-DLS
- WP2606: Exosome characterization by FFF-MALS-DLS
- WP1615: SEC-MALS for absolute biophysical characterization
- WP8003: IEX-MALS for protein separation and characterization
- WP9001: Nanoparticle Characterization with the Light Scattering Toolkit
- WP3001: Characterizing protein-DNA interactions
- WP2611: Characterization of nano-pharmaceuticals with field-flow fractionation and light scattering (FFF-MALS-DLS)
- WP5004: The Diffusion Interaction Parameter kD as an Indicator of Colloidal and Thermal Stability
- WP1003: Analyses of Polymer Branching
- Protocol: SEC-MALS protocol for analyzing BSA (on JoVE)
- AN2604: Characterization of Gold Nanoparticles with AF4-ICP-MS
- E-book: Advancing biopharma analysis with light scattering
- AN5005: Characterization and Formulation Screening of mAb and Antibody-Drug Conjugates (ADCs) by High-throughput DLS
- WP5009: Protein Quality Control in SPR and BLI High-Throughput Screening Studies
- WP1004: Absolute characterization of polymers with light scattering and UHP-SEC
- Vaccines: Time-Resolved Structural Changes and Aggregation in Influenza Virus [poster]
- Mobility of a Monoclonal Antibody: Comparison of Techniques [poster]
- Biopolymers: Heparin and PAMAM Dendrimers [poster]
- Self-Association of an Ion Transport Protein [poster]
- Aggregation of Antibody-Drug Conjugates [poster]
- Silver Nanolipids [poster]
- High Molar Mass Polysaccharides: Comparison of SEC-MALS and FFF-MALS [poster]
- Nanoparticle Analysis by FFF-ICPMS [poster]
- Hyperbranched Polyols [poster]
- Amyloid-β Derived Diffusable Ligands [poster]
- Conjugate Analysis: Lipid Transport Proteins [poster]
- Vaccines: Forced Aggregation of Antigens [poster]
- Aggregation of a Recombinant Protein: Comparison of SEC-MALS, SEC-QELS and Plate-Based DLS [poster]
- Size and Shape of Environmental Particles
- Near Real-Time Analysis of Polymers and Biopolymers
- Real-Time Monitoring of Macromolecular Complex Assembly and Disassembly
- DNA and RNA Repair Enzymes
- pH Dependent Monomer-Dimer Equilibrium Constants for Glycinamide ribonucleotide transformylase (GART)
- AN4006: Studying the performance of surfactants as chaotropic agents in protein formulation by DLS
- Vesicle Size Distribution Analysis
- Nanoparticles (NPs) and Biology
- In Situ Analysis of Inorganic and Organometallic Clusters
- Characterization of Branched Polymers by AF4-MALS
- Starches from Different Botanical Origins
- Botulism Antitoxin Characterization
- AN2613: Analysis and characterization of fluorescent nanomaterials by FFF-MALS-FD
- Identification of Nanoparticles in Instant Cappuccino
- Standard Zimm Plot
- AN3003: Lot-to-Lot Comparability Studies of Monoclonal Antibodies
- Kinetics of Covalent Thrombin-Antithrombin Association
- Binding of Thrombin-α and an Anti-Thrombin Antibody
- Competitive Binding Between Thrombin, Antithrombin III, and a Monoclonal Anti-Thrombin Antibody
- Protein-Protein-Small Molecule Interactions – Inhibition Kinetics and Dissociation
- AN3009: Self-Associating Antibody Solutions at High Concentrations
- Monoclonal Antibodies and the Preparative Use of Asymmetric Flow Field-Flow Fractionation (AF4)
- Membrane Proteins – dRI determination of detergent concentration
- Polycarbonate-Urethane
- High Temperature Branching Analysis of Metallocene Catalysts for Polyethylenes
- AN1006: Polyurethane – absolute molar mass by SEC-MALS
- Branching Analysis of PMMA
- Nylon Analyzed in Chloroform
- Branching Analysis of Synthetic Rubbers: Polybutadiene and a Butadiene-Styrene Copolymer
- Polyborane and Carborane Polymers
- Coil-Stretch Transition of High Molar Mass Polymers
- Rigid-Rod Type Polymers: Poly(n-Hexylisocyanate)
- Reaction Profiling of Polyaniline
- Poly(styrene-block-1,2-butadiene) Block Copolymers Functionalized with Ferrocenylsilane Units
- Polystyrene Nanocomposites after Melt Intercalation
- Branched Polydienes
- Oligomerization and Stability of an AAA-ATPase from Acidinus Two-Tailed Virus
- Quantum Dot Sizing by DLS
- Crystalline Eye Lens Proteins: Conformational Changes
- Binding Stoichiometry of an Antibody Fragment
- Low Molecular Weight Lens Peptides and Changes in the Oligomeric Organization of αβ-crystallin
- High Molar Mass Starches Analyzed in Batch and Microbatch Modes
- Polysaccharides: Low Molecular Weight Heparins Used as Anticoagulants
- Vaccines: Recombinant Adenovirus
- PL2609: FFF-MALS-DLS nanoDDS key publications
- AN3006: Fusion-protein complexes analyzed by CG-MALS
- AN1312: Analysis of PLGA using SEC-MALS with APC
- Protocol: IEX-MALS protocol for analyzing BSA (on JoVE)
- AN5006: Probing the aggregation rate of a Tau protein with DLS and SLS
- AN8004: Coupling MALS with preparative ionic-exchange (pIEX) for structural biology applications
- AN1616: SEC-MALS method for characterizing mRNA
- AN2002: Enzymatically Cross-linked Casein Characterized by FFF-MALS
- AN1005: Identifying Polymer Short-Chain Branching
- AN2301: Lignosulfonate analysis by AF4-MALS
- AN5002: High-Throughput Optimization of Drug Nanosuspensions
- AN7301: Molar Mass and Size of Globular and Glycoproteins by SEC-MALS-QELS
- AN1606: Assessing Ligand-Binding Assay Reagent Proteins
- AN2001: Stoichiometry and Stability of Host-Guest Protein-Peptide Complexes
- AN7601: Time-resolved Fibrin Network Formation by MALS and SAXS
- AN1611: High Speed Process Monitoring with UHP-SEC-MALS
- AN1002: Copolymer analysis: poly(styrene-co-acrylic acid)
- AN5001: High-Throughput Screening of TiO2 Nanoparticle Dispersions in Cell Culture Media
- AN2602: Size Distributions of Liposomes and Virus Particles by FFF-MALS
- AN2302: Starch amylose and amylopectin molar mass and size distributions
- AN2601: Liposome Structure and Concentration Determined by FFF-MALS-DLS
- AN3005: Evaluation binding of individual and combined domains in the bacterial flagellar motor complex by CG-MALS
- AN3004: Self-Association of Insulin: Affinity and Stoichiometry
- AN1302: Hyaluronic Acid MW and Conformation by SEC-MALS-IV
- AN4002: pH effects on stability and homogeneity of a protein complex analyzed by DLS
- AN1001: Low-Molecular-Weight Polystyrene
- AN2603: Poly(D,L-lactide-co-glycolide) Nanoparticles Sized by FFF-MALS-DLS
- AN7001: Multisegmented Block Copolymers by Click Chemistry and ATRP
- AN6001: Charge and Interaction Analysis for Predicting Antibody Formulation Stability
- AN6301: Discriminating Heparin from Chondroitin Sulfate by Charge: Mass Ratio
- AN1601: Absolute Molar Mass in UHPLC
- AN1605: Identification of Insulin Oligomeric States
- AN1609: Drug-Antibody Ratio Analysis in ADCs
- AN1608: Transient Protein Self-Association
- AN1610: Stoichiometry of Intrinsically-Disordered Protein Complexes
- AN1603: Protein Reagent Quality for Drug Discovery
- AN8002: Reverse-Phase/MALS Characterization of Protein Oligomers – Fibroblast Growth Factor
- AN8001: Gluten Characterized by Reverse-Phase Chromatography + MALS
- AN1612: Protein PEGylation Processes Characterized by SEC-MALS
- AN1613: Low-Molar-Mass Peptide Characterization by SEC-MALS
- AN1602: Lipid/membrane protein complexes analyzed by SEC-MALS
- AN1607: Kinase Fragment Oligomerization
- AN1614: Multi-protein complexes identified by SEC-MALS
- AN1307: Cellulose/DMAC Molecular Weight Distributions
- AN1310: SEC-MALS Analysis of Fluorescent Lignosulfonate Polymers
- AN1308: Chitosan Molar Mass Distributions
- AN1306: QC Validation of a Polyvalent Polysaccharide Pneumococcal Vaccine
- AN1305: Irradiation-induced degradation of sodium alginate by SEC-MALS
- AN1311: Analysis of Linear and Branched Synthetic Amyloses by SEC-MALS
- AN1303: Chondroitin Sulfate Mw and Size by SEC-MALS-QELS
- AN1301: PLGA Molar Mass and Conformation by SEC-MALS-IV
- AN1304: Low-Molecular-Weight Heparin Analysis by SEC-MALS
- AN4001: Organic-phase encapsulation in protein-based nanocapsules studied by DLS
Ask the Expert
- How do I use the HPLC CONNECT™ 4 software to control my Waters™ LC system?
- What columns do you recommend for protein and AAV applications?
- How do I set up a fraction collector method with HPLC CONNECT 3 and ASTRA?
- If my solvent includes DMSO, what do I need to know for DynaPro Plate Reader or NanoStar measurements?
- Can I use a fraction collector with an Eclipse and VISION for my FFF-MALS experiments?
- How can I validate the performances of DLS and ELS instruments?
- How can I use the Bubble Detection feature in DYNAMICS to quickly screen DynaPro Plate Reader data?
- How is ultraDAWN used in-line with FPLC to monitor chromatographic purification of AAV?
- How can I automate my Mobius™ experiments for high-throughput measurements?
- How do I collect multiple digital UV wavelengths in ASTRA® with FFF-MALS?
- Can I compare and visualize results from multiple experiments in DYNAMICS?
- Is it possible to determine molar mass, size, and relative fractions of a copolymer or protein conjugate with light scattering?
- Can RT-MALS monitor nanoparticle size and concentration when the solution is turbid?
- What resources does Wyatt offer to quantify AAV quality attributes with
SEC-MALS? - What online resources does Wyatt have for new users?
- Where can I find accessories for my Wyatt instrument?
- How does VISION SP meet compliance requirements?
- How do the new fixed-height channels make it easier to run my FFF experiments?
- Can I detect and characterize polymer branching with MALS?
- Can I integrate my DynaPro® Plate Reader with a robot in my high-throughput lab?
- Can I run IEX- or RPC-MALS experiments on an Eclipse equipped with the SEC Switching Option?
- How can I organize my results in DYNAMICS?
- How can I quickly assess the data quality of my DLS measurements using DYNAMICS?
- How do VISION 3 and DCM make it easier to install a membrane for the Eclipse?
- How do I use the Viral Vector Analysis in ASTRA 8?
- How do I use HPLC CONNECT™ software to control my Agilent HPLC or UHPLC?
- What kind of data mining can I perform on my ASTRA data?
- Do you have any tips for restarting my Wyatt Technology instruments after storage?
- How do I shut down and store my Wyatt instruments properly to ensure an easy startup?
- How do I determine particle concentrations for multimodal samples in DYNAMICS?
- How do I connect my Wyatt instruments to my chromatography system?
- How do I analyze spectral data with the 3D Viewer in VISION?
- Can I perform batch experiments with a cuvette instead of my flow cell in DAWN?
- How quickly can a shift in molar mass be detected with RT-MALS?
- What causes a “ghost” peak and what can I do to prevent this?
- How do I use the new particle concentration feature in DYNAMICS?
- What are some considerations and strategies when working with fluorescing samples?
- How can I tell if I have fluorescing or absorbing samples?
- How can I assess the quality of my chromatography in ASTRA?
- How can I develop a flow program for an unknown sample for the Eclipse FFF?
- How do the next generation of Wyatt instruments assess whether my system is ready to run?
- How do I prevent sample evaporation when using the Plate Reader?
- I need to monitor multiple UV wavelengths for my sample. How can I do this with ASTRA?
- I’m using a new solvent for my SEC-MALS runs. How do I add this solvent information to ASTRA?
- I plan to run my samples over the weekend. How can I have the instruments shutdown after the run completes if I’m not there?
- How do I create a temperature ramp study for my DynaPro Plate Reader in DYNAMICS?
- I made a change to how I process my experiments. Is there a way to easily apply this change to my existing experiments?
- Is it possible to determine molar mass, size, and relative fractions of a copolymer or protein conjugate with light scattering?
- I found the perfect mobile phase for my experiments. Now how do I find the right validation standard?
- What are your recommendations for keeping an SEC-MALS system clean for as long as possible?
bio-cgmals
- Optimizing microfluidic LNP formulations with in-line particle size and concentration measurements
- Characterizing Interactions at High Protein Concentrations by Static Light Scattering
- Screening & Characterizing Biomolecular Interactions via Light Scattering for Biotherapeutic R&D Part II – CG-MALS
- Biotherapeutics Form and Function: Case Studies in Light Scattering
- Quantifying Affinity and Stoichiometry of Biomolecular Interactions by Composition-Gradient Multi-Angle Light Scattering (CG-MALS)
bio-dls
- Well-behaved or troublemaker? How high-throughput Dynamic Light Scattering (DLS) boosts developability & stability of biotherapeutics
- Measuring the Opalescence of mAb Solutions with Microscale Nephelometry
- Stability characterization of vaccines, gene vectors and therapeutic antibodies with light scattering
- Biophysical characterization and quality control of vaccines and gene vectors with light scattering
- Using chemical denaturants and light scattering to determine aggregation propensity of biopharmaceuticals
- Virtual User Meeting – Screening for stability: Characterizing formulations with DLS
- Rational use of dynamic light scattering for the characterization of cytokines, bispecific antibody fusion proteins and binary antibody mixtures
- Predicting stability of antibody therapeutics by unfolded-state studies with high-throughput dynamic light scattering (HT-DLS)
- Characterization of Nanotherapeutics by Dynamic Light Scattering
- Developing a toolkit towards prediction of protein aggregation
- The Importance of Light Scattering in Biopharmaceutical Formulation Development
- Novel Ways of Screening Colloidal Nanoparticles Under Preclinical-relevant Conditions
- Crystallized Biotherapeutics: Optimizing mAb Crystallization using Light Scattering
- Understanding Monoclonal Antibody Unfolding and Aggregation
- ILSC Plenary: Challenges of Maintaining Structure-Function Complexity of Protein Biologics Throughout the Manufacturing Process
- High-throughput Analytics for Formulation and Process Development of Bio- and Nano-therapeutics
- Advances in High-Throughput Screening of Aggregation, Stability and Viscosity Utilizing Light Scattering in Microwell Plates
- Automation of Biologics Formulation Preparation and Stability Studies
- Screening & Characterizing Biomolecular Interactions via Light Scattering for Biotherapeutic R&D: Part I – High-Throughput Screening by DLS
bio-fffmals
- Unraveling the Complexity: Advanced Analysis of Polymeric Nanostructures
- Characterizing Critical Quality Attributes of Outer Membrane Vesicles for Conjugate Vaccines
- Therapeutic Proteins in Biological Fluids: Size Characterization Using AF4 with Fluorescence and SPR Detection
- Measuring physical properties of liposomes and LNPs for RNA delivery with multidetector asymmetric-flow field-flow fractionation
- Separation and Characterization of Macromolecules with AF4-MALS
- Probing Submicron Protein Aggregation Using Asymmetrical Flow Field-Flow Fractionation (AF4) and Light Scattering
- Characterizing Protein Conjugates and Their Aggregates by Light Scattering
- Mass, Size, Composition: Field-Flow Fractionation of Biomolecules and Nanoparticles plus Characterization by Light Scattering and ICP-MS
bio-overview
- From Proteins to AAVs and LNPs: Multi-Attribute Quantification (MAQ) by Light Scattering
- Vaccines Illuminated: Biophysical characterization, PAT, and quality control via light scattering techniques
- Size, Concentration, Payload and Quality: Comprehensive Characterization of LNP-RNA Therapeutics by Light Scattering
- Quality attributes and extended characterization of lentiviral and gammaretroviral vectors using light scattering
- Characterization and formulation of therapeutic macromolecules using light scattering
- Quantify Viral Vector Attributes with Light Scattering
- Quantification of viral and non-viral vector CQAs
- Virtual User Meeting – Viral Vectors and Bio-Nanoparticles
- Scientific Town Hall Meeting: Biophysical tools for vaccine characterization and virus research
- Quantifying Viral Vector Attributes with Light Scattering
- Molar Mass, Size, Charge, and Interactions: Light Scattering Tools for Essential Biophysical Characterization
- Vaccines, Well Characterized? Light Scattering Solutions for Biophysical Characterization in Vaccine R&D
- VLP Characterization: The Light Scattering Biophysical Toolbox
- Characterizing ADCs with the Light Scattering Toolbox
- From Mobility to Stability: Light Scattering Solutions for Formulating Stable Biotherapeutics
- Optimizing Protein Biotherapeutic Formulations with the Light Scattering Toolkit
- Characterizing Solution Properties of Biopharmaceuticals Using Light Scattering Combined with Orthogonal Analytical Approaches
- To SEC-MALS & Beyond – The Road to Biotherapeutic Development Illuminated by Light Scattering
bio-rt-mals
- Real-time analysis of product attributes in downstream processing of viral vectors
- Advances in Downstream PAT for Biologics, Vaccines and Gene Vectors
- RT-MALS: Downstream PAT for Biologics, Vaccines and Gene Vectors
- Real-Time Process Analytics and Control for Vaccine Nanoparticles and Macromolecules
- Real-Time MALS: A Breakthrough in Process Analytical Technology for Nanoparticles, Biopharmaceuticals and Polymers
bio-secmals
- Absolute Molar Mass Analysis of Medical Device and Pharmaceutical Polymers
- µSEC-MALS adds Multi-Angle Light Scattering to UHP-SEC for Measurement of Absolute Molecular Weight and Size
- Small, but bright: µSEC-MALS adds light scattering to UHP-SEC for biophysical characterization of biotherapeutics
- Innovations and Applications of UHP-SEC and Multi-Angle Light Scattering (MALS) for the Analysis of Biotherapeutic Proteins
- ILSC Plenary: SEC-MALS for the Characterization of Complex Drugs and Sugar-Protein Complexes of Immunological Importance
bylang-chinese
bylang-french
- French Virtual SEC-MALS User Meeting
- French webinar: Real-Time MALS: A Breakthrough in Process Analytical Technology for Nanoparticles, Biopharmaceuticals and Polymers
- Version Française du webinar: Adeno-associated Viruses and Viral Vectors
- Techniques de diffusion de lumière pour l’étude et la caractérisation de composés biothérapeutiques
- La SEC-MALS et au-delà: Sur la route du développent de biothérapeutiques vus par la diffusion de la lumière
bylang-german
- MALS – aber richtig! Absolute Molmassen von Proteinen und Polymeren bestimmen mit SEC MALS
- Better separation with AF4/HF5
- Verbessern Sie Ihre Proteinanalytik durch den Einsatz von Streulichtdetektoren
- Molmassen mit weniger Probe schneller und besser messen – mit dem neuen µDAWN Lichtstreudetektor für die UHPLC
bylang-hebrew
bylang-portuguese
bylang-Spanish
cgmals-bio
cgmals-nano
cgmals-overview
cgmals-proteins
- Analysis of Viral Proteins, Nucleic Acids and Biomolecular Interactions with Light Scattering
- Characterizing Protein-Nucleic Acid Interactions by Light Scattering
- Absolute Characterization of Glycoproteins and their Interactions with Proteins and Antibodies by Light Scattering
- Analyzing Ebola virus glycoprotein and its interactions with therapeutic antibodies using CG-MALS
- ILSC Plenary: The Molecular Tool-kit of Hemorrhagic Fever Viruses
dls-bio
dls-els
dls-nano
dls-overview
- A Quick Guide to Properly Measuring Zeta Potential and Particle Size for Challenging Samples
- Quickly Screen Peptides, Proteins and Nanoparticles for Size and Aggregation Using Advanced Methods
- High-Throughput, Automated Dynamic Light Scattering Using the DynaPro Plate Reader
- Automated and High-Throughput Dynamic Light Scattering Application Examples
dls-polymers
dls-proteins
- The Versatility of High-Throughput Dynamic Light Scattering in Protein Characterization and Formulation Development
- Predicting and Evaluating the Stability of Therapeutic Protein Formulations by Dynamic Light Scattering and Machine Learning
- Measuring Size, Stability and Conformation of Biopolymers with Dynamic Light Scattering
- Combining Size and Molar Mass Measurements of Proteins and Biomolecules Using the DynaPro NanoStar
- ILSC Plenary: Colloidal Aggregation in Drug Discovery & Pharmacology
els-bio
els-nano
els-overview
els-proteins
Featured Customer
- Featured Customer – Meng Jing, Ph.D.
- Featured Customer – Valerie Sim, Ph.D.
- Featured Customer – Robert Pankow, Ph.D.
- Featured Customer – Clemens Schwarzinger, Ph.D.
- Featured Customer – Brooks Abel, Ph.D.
- Featured Customer – Peter Randolph, Ph.D.
- Featured Customer – Yonggang Liu, Ph.D.
- Featured Customer – Jessica Lamb, Ph.D.
- Featured Customer – Sharee Adams-Hall
- Featured Customer – Fanny Caputo, Ph.D.
- Featured Customer – Walter Chazin, Ph.D.
- Featured Customer – Kristina Djinović Carugo, Ph.D.
- Featured Customer – Marius Schmid, Ph.D.
- Featured Customer – Judit Puskas, Ph.D.
- Featured Customer – Garret Smith
- Featured Customer – Nina Simon, Ph.D.
- Featured Customer – Kevin Balcaen, Ph.D.
- Featured Customer – Aleksandr (Alex) V. Zhukhovitskiy, Ph.D.
- Featured Customer – Adam Gormley, Ph.D.
- Featured Customer – Donald Johnson, Ph.D.
- Featured Customer: Ozan Kumru, Ph.D.
- Featured Customer: Laxman Mainali, Ph.D.
- Featured Customer: Kyle Bentz, Ph.D.
- Featured Customer: Matthew Golder, Ph.D.
- Featured Customer: Sergio Paulo Campana Filho, Ph.D.
- Featured Customer: Bryan Troxell, Ph.D.
- Featured Customer: Karsten Melcher, Ph.D.
- Featured Customer: Kevin Sill, Ph.D.
- Featured Customer: Sameer Kale, Ph.D.
- Featured Customer: Travis Walker, Ph.D.
- Featured Customer: Libor Kostka, Ph.D.
- Featured Customer: Darren Begley, Ph.D.
- Featured Customer: Thomas Müller, Ph.D.
- Featured Customer: Maruti Hegde, Ph.D.
- Featured Customer: Amandaa Brewer, Ph.D.
- Featured Customer: Dmitry Lyumkis, Ph.D.
- Featured Customer: Hao Guo
- Featured Customer: Li Zhu, Ph.D.
- Featured Customer: SOLVE Research and Consultancy
- Featured Customer: Edwin Moore, Ph.D.
- Featured Customer: Greg Wasney, Ph.D.
- Featured Customer: James Shih, Ph.D.
- Featured Customer: Andrew Lyon, Ph.D.
- Featured Customer: Stacey Louie, Ph.D.
- Featured Customer: Paul DeAngelis, Ph.D.
- Featured Customer: Lynette Schroeter Tedesco, Ph.D.
- Featured Customer: David Cistola, Ph.D.
- Featured Customer: Douglas Biomimetic Materials Lab
- Featured Customer: Carlo Zambonelli, Ph.D.
- Featured Customer: Frederic Violleau, Ph.D.
- Featured Customer: Sheena D’Arcy, Ph.D.
- Featured Customer: Jason Todd
- Featured Customer: Charles Diesendruck, Ph.D.
- Featured Customer: John Matson, Ph.D.
- Featured Customer: Jon Pokorski, Ph.D.
- Featured Customer: Professor Stuart Rowan
- Featured Customer – Professor Christopher Ellison
- Featured Customer: Frank von der Kammer, Ph.D.
- Featured Customer: Donna Luisi, Ph.D.
- Featured Customer: Wei Gao, Ph.D.
- Featured Customer: Ewa Folta-Stogniew, Ph.D.
- Featured Customer: Allen P. Minton, Ph.D.
- Featured Customer: Chris Johnson, Ph.D.
Featured Publications
- Towards an improved prediction of concentrated antibody solution viscosity using the Huggins coefficient
- View our latest featured publication in Analytica Chimica Acta: X
Differential light scattering and the measurement of molecules and nanoparticles: A review - Replacement of Arg in the conserved N-terminal RLFDQxFG motif affects physico-chemical properties and chaperone-like activity of human small heat shock protein HspB8 (Hsp22)
- Detection, counting and characterization of nanoplastics in marine bioindicators: a proof of principle study
- High‐throughput identification of conditional MHCI ligands and scaled‐up production of conditional MHCI complexes
- Asymmetric Flow Field-Flow Fractionation: Current Status, Possibilities, Analytical Limitations and Future Trends
- Characterization and purification of pentameric chimeric protein particles using asymmetric flow field-flow fractionation coupled with multiple detectors
- Intravitreal Polymeric Nanocarriers with Long Ocular Retention and Targeted Delivery to the Retina and Optic Nerve Head Region
- Detailed Protocol for the Novel and Scalable Viral Vector Upstream Process for AAV Gene Therapy Manufacturing
- Comprehensive characterization and quantification of adeno associated vectors by size exclusion chromatography and multi angle light scattering
- Asymmetric-flow field-flow fractionation for measuring particle size, drug loading and (in)stability of nanopharmaceuticals. The joint view of European Union Nanomedicine Characterization Laboratory and National Cancer Institute – Nanotechnology Characterization Laboratory
- High-Throughput Analytical Light Scattering for Protein Quality Control and Characterization
- A protocol for Asymmetric-Flow Field-Flow Fractionation (AF4) of small extracellular vesicles
- Recent applications of light scattering measurement in the biological and biopharmaceutical sciences
- Analysis of polysaccharide and proteinaceous macromolecules in beer using asymmetrical flow field-flow fractionation
- The role of electrostatics in protein-protein interactions of a monoclonal antibody
- Characterization of molecular structure of acrylic copolymers prepared via emulsion polymerization using A4F-MALS technique
- Algorithm-driven high-throughput screening of colloidal nanoparticles under simulated physiological and therapeutic conditions
- Calcium-dependent stoichiometries of the KCa 2.2 (SK) intracellular domain/calmodulin complex in solution
- Methodologies for analyzing protein aggregation
- A new concept for the treatment of atopic dermatitis: Silver-nanolipid complex (sNLC)
- Free-solution, label-free protein-protein interactions characterized by dynamic light scattering
- Hybrid structural model of the complete human ESCRT-0 complex
- Membrane scission by the ESCRT-III complex
- Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
- Structural basis for recognition of diubiquitins by NEMO
- Characterizing stable protein formulations
- Architecture of a coat for the nuclear pore membrane
- Design and testing for a nontagged F1-V fusion protein as vaccine antigen against bubonic and pneumonic plague
- Structure of nerve growth factor complexed with the shared neurotrophin receptor p75
- Oxidized mono-, di-, tri-, and polysaccharides as potential hemoglobin cross-linking reagents for the synthesis of high oxygen affinity artificial blood substitutes
- An optical marker based on the UV-induced green-to-red photoconversion of a fluorescent protein
- Molecular architecture of the transport channel of the nuclear pore complex
- Rational design of low-molecular weight heparins with improved in vivo activity
- Insights into the respiratory electron transfer pathway from the structure of nitrate reductase A
- Chaperonin-mediated stabilization and ATP-triggered release of semiconductor nanoparticles
- Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp 130 complex
- Crystal structure of a tetradecameric assembly of the association domain of Ca2+/Calmodulin-dependent kinase II
- An “endless” route to cyclic polymers
- Structural evidence for feedback activation by Ras-GTP of the Ras-specific nucleotide exchange factor SOS
- High-throughput assays for promiscuous inhibitors
- Characterization of hyaluronic acid with on-line differential viscometry, multi-angle light scattering, and differential refractometry
- Light scattering based analysis of biomolecular interactions
- Effects of ionic strength and sugars on the aggregation propensity of monoclonal antibodies: Influence of colloidal and conformational stabilities
- A systematic multitechnique approach for detection and characterization of reversible self-association during formulation development of therapeutic antibodies
- Utilizing dynamic light scattering as a process analytical technology for protein folding and aggregation monitoring in vaccine manufacturing
- Truths and myths about the determination of molar mass distribution of synthetic and natural polymers by size exclusion chromatography
- Measurement of special nanoparticle structures by light scattering
- Protein-protein interactions investigated by DLS
fff-mals
fffmals-bio
fffmals-nano
- Multi-Detector Asymmetric-Flow Field-Flow Fractionation for Nanoparticle Analysis in Complex Matrices
- Characterization of Lipid Nanoparticle Drug Formulations
- Separation and Characterization of Macromolecular and Supramolecular Structures by Light Scattering
- Drug Delivery Nanoparticles, Illuminated: The Light Scattering Toolkit – Part 2, Online Measurements
fffmals-overview
- Expanding the Characterization Toolkit with FFF-MALS: Developments, Techniques, and Applications
- A breakthrough development in FFF-MALS – raising performance and usability to a new level
- Virtual User Meeting – New Methods and Applications in Field Flow Fractionation
- Virtual User Meetings & Workshops – The Light Scattering Toolbox: SEC-MALS-DLS and FFF
- Latest Advancements in Absolute Characterization of Proteins, Polymers and Nanoparticles
- Separation and Characterization of Complex (Bio)macromolecular Architectures
- FFF 2.0: Obtaining high resolution distributions of nanoparticle size and zeta potential, with less time, less effort and more confidence
- Field-Flow Fractionation Combined with Multi-Angle Light Scattering
fffmals-polymers
- Polymer Characterization Using Field-Flow Fractionation Combined with Multi-Angle Light Scattering
- Advantages of FFF-MALS over SEC-MALS for the Determination of Molar Mass and Size Distribution of Polysaccharides
- Solving SEC/GPC Limitations with Multi-Angle Light Scattering and Asymmetric-Flow Field-Flow Fractionation
- Understanding Polymer Properties with Multi-Angle Light Scattering
- Structural characterization of functional polymers via light scattering and differential viscometry
- Structural Characterization of Biopolymers by Analytical Separation Techniques with Advanced Detectors
- AF4-MALS: A Powerful Tool for the Characterization of Biomacromolecules and Colloidal Particles
- Essential Polymer Characterization: The Benefits of Multi-Angle Light Scattering (MALS) and Field Flow Fractionation (FFF) for Determining Molecular Weights, Sizes and Branching Ratios
- Branching Revealed: Characterizing Molecular Structure in Synthetic and Natural Polymers by Multi-Angle Light Scattering
fffmals-proteins
Gated Webinars
- Request: Unraveling the Complexity: Advanced Analysis of Polymeric Nanostructures
- Request: Multi-Detector Asymmetric-Flow Field-Flow Fractionation for Nanoparticle Analysis in Complex Matrices
- Request: Successful SEC-MALS analysis of proteins and AAVS
- Request: Well-behaved or troublemaker? How high-throughput Dynamic Light Scattering (DLS) boosts developability & stability of biotherapeutics
- Request: Characterizing Critical Quality Attributes of Outer Membrane Vesicles for Conjugate Vaccines
- Request: Measuring the Opalescence of mAb Solutions with Microscale Nephelometry
- Request: Real-time analysis of product attributes in downstream processing of viral vectors
- Request: From Proteins to AAVs and LNPs: Multi-Attribute Quantification (MAQ) by Light Scattering
- Request: Polymer Characterization Using Field-Flow Fractionation Combined with Multi-Angle Light Scattering
- Request: Optimizing microfluidic LNP formulations with in-line particle size and concentration measurements
- Request: Exploring protein oligomerization and stoichiometry with SEC-MALS: Case studies from phage-bacteria conflict
- Request: Advantages of FFF-MALS over SEC-MALS for the Determination of Molar Mass and Size Distribution of Polysaccharides
- Request: Advances in Downstream PAT for Biologics, Vaccines and Gene Vectors
- Request: Vaccines Illuminated: Biophysical characterization, PAT, and quality control via light scattering techniques
- Request: Experimental methodology in a core facility: Light scattering for preliminary experiments and final answers
- Request: Stability characterization of vaccines, gene vectors and therapeutic antibodies with light scattering
- Request: Solving SEC/GPC Limitations with Multi-Angle Light Scattering and Asymmetric-Flow Field-Flow Fractionation
- Request: Machine learning with light scattering to design complex copolymers
- Request: SEC-MALS Characterization of Block Copolymers
- Request: Biophysical characterization and quality control of vaccines and gene vectors with light scattering
general
Library
- Successful SEC-MALS analysis of proteins and AAVS
- Request AN8006
- Request AN1616
- Request WP2608
- Measuring physical properties of liposomes and LNPs for RNA delivery with multidetector asymmetric-flow field-flow fractionation request
- Size, Concentration, Payload and Quality: Comprehensive Characterization of LNP-RNA Therapeutics by Light Scattering Request
- Request PL9008
- Request the Application Note AN2004
- Request White Paper WP5003
- Request AAV Application Notebook
- Request AN1617
- Request AN2004
- Request WP5003
- Request WP1615
- Exploring protein oligomerization and stoichiometry with SEC-MALS: Case studies from phage-bacteria conflict
- Experimental methodology in a core facility: Light scattering for preliminary experiments and final answers
- Using SEC-MALS in Protein Characterization and Structural Studies in the Biocenter Oulu Structural Biology Core Facility
- Looking at proteins from different angles: The unusual behavior of phospholipase PlaB from Legionella pneumophila
- SEC-MALS Characterization of Block Copolymers
- Upcycling Polyolefins into Value-Added Thermoplastics, Assisted by SEC-MALS
- Quality Attributes and Extended Characterization of Lentiviral and Gammaretroviral Vectors Using Light Scattering
- Shining a Light on Conjugated Polymers with GPC-MALS
- ultraDAWN: Real-Time DSP Analytics Using Light Scattering
- Characterizing Polymers and Polymer Aggregates Using SEC-MALS and Batch-Mode MALS
- Virtual User Meeting – Polymers, Light Scattering, Viscometry
- Analysis of viral proteins, monoclonal antibodies and their interactions with light scattering
- Real-Time Process Analytics and Control for Vaccine Nanoparticles and Macromolecules
nano-dls
nano-els
nano-fffmals
nano-overview
nano-rt-mals
Newsletter Archive
- Multi-Angle: September 2023
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polymers-dls
polymers-els
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- Using SEC-MALS-IV to Characterize PLGA for FDA Generic Drug Approval
- Multi-Detector SEC Characterization of Polymer Architectures
- Development of a New Online Micro-Viscometer for APC and UHPLC Applications
- Characterizing Molecular Structure in Synthetic and Natural Polymers by Multi-Angle Light Scattering
- Absolute Characterization of Polymeric Excipients with Size Exclusion Chromatography and Light Scattering
proteins-cgmals
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proteins-els
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- Understanding Absolute Stoichiometry of Oligomeric Protein Complexes Using SEC-MALS
- Applications of Analytical Light Scattering in a Biophysics Core Facility
- Applications of Light Scattering to HIV Integrase Structural Biology and Drug Discovery
- For Effective Protein Quality Control and Aggregate Detection, Couple SEC to Multi-Angle Light Scattering (SEC-MALS)
- A World of Difference: Wyatt Protein Columns for Enhanced SEC-MALS Analysis
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sec-mals
secmals-bio
secmals-nano
secmals-overview
secmals-polymers
secmals-proteins
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Part 1: The early years - ASTRA’s new LNP-RNA Analysis quantifies payload,
encapsulation efficiency and more - Announcing the 2022 George E. Pake Award Recipient – Dr. Philip Wyatt
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- Drug discovery: Finding, Then Losing, Then Finding Again Colloidal Aggregates of Small-molecule Drugs with DLS
- Silver Seal of Quality Awarded for DAWN
- Joining Forces for Faster Analyses
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- Protein Quality Control in SPR and BLI High-Throughput Screening Studies
- Wyatt Presents Polymer Characterization Seminar Hosted by the University of Minnesota
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- Reviewer’s Choice Awarded for DAWN
- DynaPro High-Throughput Dynamic Light Scattering Now Available with 21 CFR Part 11 Compliance
- New Application Note: Assessing Ligand-Binding Assay Reagent Proteins by SEC-MALS
- FDA and NIH investigate HT-DLS for nanoparticle stability
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- ViscoStar III – Innovations in Online Viscometry for GPC
- We’re moving! Just not very far…
- Wishing you the best of Holidays
- Commercializing multi-angle light scattering instruments – an interview with Philip Wyatt
- Sigma Xi inducts 12 Wyatt Technology scientists
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- Chemistry Nobel Prize Awarded to Sir James Fraser Stoddart
- Highlights: Light Scattering Reveals Novel Applications of DNA
- The myriad applications of quantitative light scattering in the biological and biopharmaceutical sciences
- Retooling Protein Characterization
- ZoBio Optimizes Solution Behavior of Proteins
- Wyatt’s International Light Scattering Colloquium focuses on the nano world
- Light Scattering in the Nano World
- Wyatt Technology Europe to participate in the “Marie Skłodowska-Curie” protein formulation consortium
- HIGHLIGHTS: Recent Publications in the Field of Natural Polymers
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- Wyatt Technology’s Growth Continues…
- ILSC 2015: Scattered Light