AN6004: Automated, High-Precision Liposome Zeta Potential Measurements at High and Low Salt Concentrations

Zeta potential is used as a key metric for colloidal suspension stability for a wide range of applications, including biopharmaceuticals, cosmetics, foods, paints, coatings, and water treatment. The general usefulness of zeta potential measurements has, however, been held back by instruments limited to time-consuming, low-precision measurements within a narrow and often unsuitable ionic strength range.

This application note demonstrates how the DynaPro™ ZetaStar™ instrument allows scientists to go beyond these limitations, delivering automated measurements of biomolecule and nanoparticle zeta potential, size, and polydispersity at both low and high ionic strengths with excellent precision and accuracy. This high-precision instrument can facilitate and accelerate drug development, formulation, and quality control and help build improved models of biomolecular electrostatics.