Exploring Antibody Stability Through Light Scattering and Calorimetry Techniques
Presented by: Christine Nervig (TA Instruments) and Sophia Kenrick (Waters Corporation)
Presented Live: October 7, 2025
High-concentration antibody formulations provide patients with the flexibility of self-administered subcutaneous dosing. However, achieving stability and manufacturability of these solutions can lead to increasingly complex formulation development. With expansive libraries of protein variants and formulation conditions to evaluate, researchers need smarter, faster, and more comprehensive analytical tools to ensure chemical stability and optimal delivery characteristics.
In this webinar, we present complementary approaches to stability characterization, leveraging high-throughput technologies:
- High-Throughput Dynamic and Static Light Scattering (DLS/SLS): These techniques provide rapid, sensitive indicators of aggregation and colloidal stability across a wide range of conditions.
- Rapid Screening-Differential Scanning Calorimetry (RS-DSC): This next-generation DSC platform enables simultaneous, low-volume measurements to assess protein unfolding and conformational stability with exceptional throughput.
Together, these complementary methods offer a high-resolution, —empowering scientists to make faster, data-driven decisions in the development of stable, effective biologics.