Advances in Downstream PAT for Biologics, Vaccines and Gene Vectors [Poster]

Multi-angle light scattering (MALS) is a versatile technology most commonly found in analytical laboratories for characterizing biophysical properties such as protein or polynucleotide molar mass, size and conformation; size and concentration of virions; and the genomic payload of viral and non-viral gene vectors.

Real-time multi-angle light scattering (RT-MALS) is a novel use of MALS which brings many of those capabilities to preparative systems and process development laboratories. RT-MALS determines key product attributes of biologics, in-line or on-line with downstream and fill-finish processes, and can be used to monitor aggregation, distinguish product from impurities, identify process endpoints and more.