Amyloid-β Derived Diffusable Ligands [poster]

Amyloid β is a peptide naturally synthesized in the human brain at low levels. Over-expression, or lack of clearance of this peptide will result in the formation of insoluble protein fibers which bundle together to form amyloid plaques, a hallmark of the neurodegenerative disorder known as Alzheimer’s disease. We have used analytical ultracentrifugation and size exclusion chromatography coupled with multi-angle laser light scattering to characterize various amyloid β preparations with the ultimate goal of being to correlate those results with the results of in-vitro toxicity assays and cell binding studies.