AN1312: Analysis of PLGA using SEC-MALS with APC

PLGA Analysis

Determining the properties of PLGA is crucial in product formulation. Of particular importance is molecular weight (Mw), which influences polymer strength and ease of processing into products. Size-exclusion chromatography with multi-angle light scattering and intrinsic viscosity detection (SEC-MALS-IV) is an ideal technique to characterize PLGA: size and conformation are calculated along with absolute molecular weight. This ability to capture multiple properties of PLGA takes on greater importance as companies attempt to make generic versions of drugs containing PLGA.