Calsequestrin, a Calcium Storage Protein

The sarcoplasmic reticulum (SR) plays an essential role in muscle excitation-contraction coupling by regulating the cytosolic free Ca2+ concentration. In order to study the plausible coupling between the Ca2+ binding and the polymerization of CSQs, we have for the first time employed Multi-Angle Light Scattering (MALS) for the exact measurement of Ca2+ dependent polymeric state of CSQs.