Characterization of α-synuclein Oligomerization

α Synuclein Oligomerization

The aggregation of the presynaptic protein αsynuclein is believed to play a critical role in Parkinson’s disease. It is suspected that pre-fibrillar oligomers, rather than fibrils themselves, may be the cytotoxic form. In the present experiment we used dynamic light scattering to monitor buildup and decay of oligomeric intermediates during the early stages of a-synuclein fibrillation in vitro.