WP4005: Determination of critical micelle concentration by dynamic light scattering

The critical micelle concentration of detergents have been characterized in solution by a variety of methods, including surface tension measurements, gel permeation chromatography, and fluorescence and absorbance spectroscopy, all of which have significant drawbacks for this purpose. Light scattering on the other hand, has the advantages of being non-perturbing, rapid, and easy to perform, while providing meaningful physical properties such as micelle size and concentration.