Response Regulator Activation

Response Regulator

Bacteria use two-component signal transduction pathways, which comprise a histidine kinase (HK) and a response regulator protein (RR). Extracellular stimuli sensed by the HK induce an autophosphorylation reaction at a histidine residue of the enzyme that is subsequently transferred to a specific aspartate residue at the receiver domain of a cognate RR.