Ribosomal Subunits in Protein Biosynthesis

Protein Biosynthesis

The L7/L12 stalk of the large ribosomal subunit plays crucial roles in protein biosynthesis, contacting most of the translation factors and stimulating their GTP hydrolysis. To elucidate its mechanism of action on the ribosome, we have determined the crystal structure of the protein L10 in complex with L12 Nterminal domain (NTD) from the hyperthermophilic bacterium Thermotoga maritima.