AN3009: Self-Associating Antibody Solutions at High Concentrations

Self-associating Antibody

The characterization of therapeutic protein formulations is essential for the development of novel biopharmaceuticals. In particular, solution viscosity and colloidal stability may be adversely impacted by attractive self-interactions among protein molecules. In this study, we quantified the self-association affinity and stoichiometry of three antibody formulations (mAbs A, B, and C) in their corresponding formulation buffers using composition-gradient multi-angle light scattering (CG-MALS) automated by the Wyatt Calypso®.