Unlocking Precision: An Orthogonal Approach for Comprehensive AAV Characterization

Presented by: Ben Draper, Ph.D., MegaDalton Solutions and Sophia Kenrick, Ph.D., Waters | Wyatt Technology
Presented Live: May 30, 2024

As the field of gene therapy progresses, processes to produce this life-changing therapy may introduce impurities that can significantly impact its performance and quality. Notably, empty AAV capsids represent a critical product-related impurity, necessitating accurate analytical methods to measure their levels. Our webinar will delve into the development and optimization of a size exclusion chromatography with UV and multiangle light scattering (SEC-MALS). We will also explore the full-to-empty ratio as well as the quantification of particals using charge detection mass spectrometry (CDMS). Join us to learn more about how SEC-MALS and CDMS can revolutionize analytical development and quality control testing. Additionally, discover how the standard AAV Method Implementation and Training Service, as well as SOP Guidance Manual, can facilitate the adoption of advanced technology as a platform method for AAV development and production.

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