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Absolute Characterization of Polymeric Excipients with Size Exclusion Chromatography and Light Scattering


Presented Live: September 21, 2017

In a pharmaceutical drug the excipients can make up 90% of the total mass. Excipients therefore play an important role in the performance of a drug. For example, the molar mass and branching degree of polymer excipients impact the viscosity and rate of drug release. In this webinar we show how light scattering is an excellent tool to characterize the molar mass, viscosity, branching degree, conformation, conjugation, and size of excipients.





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Wyatt Technology is the recognized leader in light scattering instrumentation and software for determining the absolute molar mass, size, charge and interactions of macromolecules and nanoparticles in solution.

Wyatt's line of multi-angle static light scattering products couple to size exclusion chromatography (SEC-MALS), field-flow fractionation (FFF-MALS), and stop-flow composition-gradient systems (CG-MALS). Our dynamic light scattering (DLS) products operate in traditional cuvette as well as on-line and automated, high-throughput modes. We also offer unique instruments for electrophoretic light scattering (MP-PALS), differential refractometry, and differential viscosity.

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